β-榄香烯对神经病理性疼痛模型大鼠神经功能及ERK,CREB,BDNF表达的影响Effect of β-elemene Increased ERK,CREB and BDNF Expression in Rat Model of Neuropathic Pain Associated with Nerve Function Protection
张伟骏,陈眉,张丽娟,徐良
摘要(Abstract)：
目的观察β-榄香烯对神经病理性疼痛模型大鼠神经功能保护及对模型大鼠脊髓背根神经节ERK mRNA、CREB mRNA、BDNF mRNA表达的的影响。方法建立神经病理性疼痛大鼠模型,对各组大鼠进行热痛觉过敏行为测试;Realtime PCR检测模型大鼠脊髓背根神经节ERK mRNA、CREB mRNA,以及BDNF mRNA表达。结果假手术组无明显神经功能障碍;与模型组比较,中药组(β-榄香烯)能明显上调模型大鼠热板及机械刺激后的痛阈(P<0.05或0.01),且ERK mRNA、CREB mRNA以及BDNF mRNA的表达较模型组明显上调(P<0.05或0.01)。结论β-榄香烯可改善模型大鼠热痛觉,上调神经病理性疼痛模型大鼠脊髓背根神经节ERK mRNA、CREB mRNA、BDNF mRNA表达从而促进神经元修复。
关键词(KeyWords)： β-榄香烯;神经病理性疼痛;ERK;CREB;BDNF;实时荧光定量;PCR
基金项目(Foundation): 浙江省卫生厅科研课题(2013KYA139)
作者(Author): 张伟骏,陈眉,张丽娟,徐良
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