刘佑晖,李琰,蔡虎志,陈青扬,吴晓霞,陈广,马宁,陈新宇

• 1:湖南中医药大学
• 2:湖南中医药大学第一附属医院

摘要(Abstract)：

目的观察温阳振衰颗粒对慢性肾功能衰竭患者临床疗效及血清结缔组织生长因子(CTGF)、转化生长因子-β1(TGF-β1)的影响。方法将患者60例按随机数字表法分为对照组和观察组各30例,对照组给予西医常规基础治疗,观察组在此基础上给予温阳振衰颗粒治疗,两组患者均接受8周的治疗。观察两组的疗效,比较治疗前后肌酐清除率(Ccr)、血肌酐(Scr)、尿素氮(BUN)、血清CTGF、TGF-β1的水平。结果观察组综合疗效、中医症候疗效总有效率明显高于对照组(P<0.05);治疗后,观察组血清CTGF、TGF-β1明显低于对照组(P<0.01);观察组的Ccr、Scr、BUN亦明显低于对照组(P<0.05)。结论温阳振衰颗粒可明显改善慢性肾功能衰竭患者的肾纤维化,对慢性肾功能衰竭有较好的疗效。

关键词(KeyWords)： 温阳振衰颗粒;慢性肾功能衰竭;CTGF;TGF-β1

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81704061);; 湖南省研究生科研创新项目(CX2017B433)

作者(Author): 刘佑晖,李琰,蔡虎志,陈青扬,吴晓霞,陈广,马宁,陈新宇

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