孙海燕,张飞虎,孔立,刘阳

• 1:山东中医药大学附属医院
• 2:山东中医药大学

摘要(Abstract)：

重症急性胰腺炎(SAP)常伴有多器官功能衰竭,为临床常见的急腹症之一,病死率极高。血红素加氧酶-1(HO-1)与SAP关系及中医治疗对SAP进程中HO-1水平的调控作用成为近年来的研究热点。本文立足于几年来的文献资料,对该领域的研究成果做一综述。

关键词(KeyWords)： 重症急性胰腺炎;血红素加氧酶-1;中医药

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81503543);; 山东省自然科学基金资助项目(ZR2015HL058)

作者(Author): 孙海燕,张飞虎,孔立,刘阳

参考文献(References)：

• [1]Peery AF,Dellon ES,Lund J,et al.Burden of gastrointestina disease in the United States:2012 update[J].Gastroenterology,2012,143:1179-1187.
• [2]Zhu X,Fan WG,Li DP,et al.Heme oxygenase-1 system and gastronintestinal inflammation:a short review[J].World JGastroenterol,2011,17(38):4283-4288.
• [3]Ryters W,xis C,Hartefieidc L.Mitogen activeted protein kinase(mapk)pathwya regulates heme oxygenase-1 gene expression by hypoxia in vascular cells[J].Antioxid Redox Signa1,2002,4(4):587-592.
• [4]Morse D,Pischke SE.Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1[J].J Biol Chem,2003,278:36993-36998.
• [5]Otterbein LE,Choi AM.Heme oxygenase:colors of defense against cellular stress[J].Am J Physiol Lung Cell Mol Physiol,2000,279:1029-1037.
• [6]Ha YM,Ham SA,Kim YM,et al.β1-adrenergic receptormediated HO-1 induction,via PI3K and p38 MAPK,by isoproterenol in RAW 264.7 cells Ieads to inhibition of HMGB1release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice[J].Biochem Pharmacol,2011,82(7):769-777.
• [7]Kim HS,Park EJ,Park SW,et al.A tetrahydroisoquinoline alkaloid THI-28 reduces LPS-induced HMGB1 and diminishes organ injury in septic mice through p38 and PI3K/Nrf2/HO-1signals[J].Int Immunopharmacol,2013,17(3):684-692.
• [8]Kim SR,Ha YM,Kim YM,et al.Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals[J].Biochem Pharmacol,2015,95(4):279-289.
• [9]Park EJ,Park SW,Kim HJ,et al.Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of heme oxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo[J].Int Immunopharmacol,2014,22(2):332-340.
• [10]Wang F,Meng Y,Zhang Y,et al.Ketamine reduces lipopolysaccharide-induced high-mobility group box-1 through heme oxygenase-1 and nuclear factor erythroid 2-related factor 2/p38 mitogen-activated protein kinase[J].J Sug Res,2015,194(2):599-613.
• [11]Zhang FH,Sun YH,Fan KL,et al.Protective effect of heme oxygenase-1 against severe acute pancreatitis via inhibition of tumor necrosis factor-αand augmentation of interleukin-10[J].BMC Gastroenterol,2017,17(1):100.
• [12]Gulla A,Evans BJ,Navenot JM,et al.Heme oxy genase-1gene promoter polymorphism is associated with the development of necrotizing acute pancreatitis[J].Pancreas,2014,43(8):1271-1276.
• [13]梁英健,李鑫,张晓娟,等.NF-κB在脓毒症血浆诱导的内皮细胞损伤和凋亡中的作用[J].中国病理生理杂志,2013,29(8):1508-1511.
• [14]Kook SH,Choi KC,Lee YH,et al.Raphanus sativus L.seeds prevent LPS-stimulated inflammatory response through negative regulation of the p38 MAPK-NF-κB pathway[J].Int Immunopharmacol,2014,23(2):726-734.
• [15]Li YY,Huang SS,Lee MM,et al.Anti-inflammatory activities of cardamonin from Alpinia katsumadai through heme oxygenase-1 induction and inhibition of NK-κB and MAPK signaling pathway in the carrageenan-induced paw edema[J].In Immunopharmacol,2015,25(2):332-339.
• [16]Gong X,Zhang L,Jiang R,et al.Anti-inflammatory effects o mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1[J].J Nutr Biochem,2013,24(6):1173-1181.
• [17]Ha YM,Ham SA,Kim YM,et al.β1-adrenergic receptormediated HO-1 induction,via PI3K and p38 MAPK,by isoproterenol in RAW 264.7 cells Ieads to inhibition of HMGB1release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice[J].Biochem Pharmacol,2011,82(7):769-777.
• [18]Sato H,Siow RC,Bartlett S,et a1.Expression of stress proteins heme oxygenase-1 and-2 in acute pancreatitis and pancreatic islet betaTC3 and acinar AR42Jcells[J].FEBSLet,1997,405(2):219-223.
• [19]Thomas B,Andreas MV,Taivankhuu T,et a1.Induction o heme oxygenase-1 improves the survival of pancreas grafts by prevention of pancreatitis after transplantation[J].Transplantation,2007,84(12):1644-1655.
• [20]陈紫千,汤耀卿.白细胞介素-10基因转染急性胰腺炎的研究现状[J].国外医学:外科学分册,2004,31(2):75,77.
• [21]Nakamichi I,Habtezion A,Zhong B,et al.Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction[J].J ClinInvest,2005,115(11):3007-3014.
• [22]王志威,毛恩强,汤耀卿,等.血红素加氧酶-1对重症胰腺炎大鼠模型保护作用的研究[J].外科理论与实践,2010,15(1):19-22.
• [23]张磊,张飞虎,潘曙明,等.血红素加氧酶-1高表达对重症急性胰腺炎大鼠脏器功能的保护作用及其机制[J].肝胆胰外科杂志,2013,25(3):210-214.
• [24]张敏,朱德增.中药治疗胰腺炎的规律[J].世界华人消化杂志,2007,15(27):2945-2948.
• [25]付振帅.通理攻下中药对重症急性胰腺炎患者的临床疗效影响[J].中国医药指南,2017,15(29):4-5.
• [26]杨卫生,吴峰,周芩,等.大黄芒硝汤联合参麦注射液辅助治疗重症急性胰腺炎疗效观察[J].中国中西医结合消化杂志,2017,25(1):59-60.
• [27]吴晓英,陈易,汤金海,等.血必净静脉滴注联合生大黄治疗重症急性胰腺炎的疗效观察[J].中国继续医学教育,2018,21(9):187-188.
• [28]Yadav D,O′Connell M,Papachristou GI.Natural history following the first attack of acute pancreatitis[J].Am J Gastroenterol,2012,107:1096-1103.
• [29]Zerem E.Treatment of severe acute pancreatitis and its complications[J].World J Gastroenterol,2014,20(38):13879-13892.
• [30]中华医学会外科学分会胰腺外科学组.急性胰腺炎诊疗指南(2014)[J].中华外科杂志,2015,53(1):50-53.
• [31]赵华北,耿强.中西医结合治疗重症急性胰腺炎22例[J].甘肃中医学院学报,2004,21(4):284.
• [32]魏晓.赤芍煎剂治疗重症胰腺炎及对大鼠体内炎症介质的影响[D].上海:第二军医大学,2007.
• [33]赵祥.甘遂对重症胰腺炎炎症“瀑布效应”相关因子影响的研究[D].广州:广州中医药大学,2016.
• [34]吴洋,夏中元.参附注射液对肠缺血再灌注大鼠肾组织HO-1与iNOS表达的影响[J].中华中医药杂志,2010,25(7):1024-1026.
• [35]Zhang F,Fei J,Zhao B,et al.Protective effect of adenoviral transfer of heme oxygenase-1 gene on rats with severe acute pancreatitis[J].Am J Med Sci,2014,348(3):224-231.