李兆霞,许才明,罗亚岚,蒋柳,张桂信,陈海龙

• 1:大连医科大学附属第一医院
• 2:大连医科大学

摘要(Abstract)：

重症急性胰腺炎(SAP)是一种临床常见的急危重症,具有起病急、进展快、病情凶险的特点。SAP易使肠道受累,诱发肠道屏障功能损伤,促使肠道菌群及内毒素移位,触发全身炎症反应综合征(SIRS)和多器官功能障碍综合征(MODS),甚至导致死亡。根据SAP的临床特征,中医学将其归属于"阳明腑实证"的范畴。近年来大黄在SAP、脓毒症等危急领域的基础研究和临床应用越来越多,获得了广泛学者的认可。现代研究亦证实大黄及活性成分在对抗炎症反应、保护胃肠道黏膜屏障等方面发挥了重要作用。本文将综述大黄保护SAP肠道屏障的作用机制。

关键词(KeyWords)： 重症急性胰腺炎;大黄;肠道屏障损伤;作用机制;综述

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81573751);; 辽宁省自然科学基金项目资助(2019-ZD-0919)

作者(Author): 李兆霞,许才明,罗亚岚,蒋柳,张桂信,陈海龙

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