复方钩藤片对自发性高血压大鼠的降压作用及其机制Antihypertensive Effect and Mechanism of the Fufanggouteng Tablet on Spontaneous Hypertensive Rats
谭元生,王宇红
摘要(Abstract)：
目的初步探讨复方钩藤片对自发性高血压大鼠(SHR)的降压作用及机制。方法选择16周龄雄性SHR 40只分为:模型组,复方钩藤片高、中、低剂量组,替米沙坦组,另纳入8只同龄雄性WKY大鼠为正常对照组,干预持续28d。采用无创尾动脉法观察复方钩藤片对SHR的降压作用;放免分析法测定血浆醛固酮、内皮素含量;HR染色观察肾、海马组织的形态学变化。结果复方钩藤片高、中剂量可明显降低血压、血浆醛固酮、内皮素的含量,与模型组比较有显著差异;同时可明显减轻肾、脑的病理损害。结论复方钩藤片对SHR有降压作用,其降压机制可能与降低SHR血浆醛固酮、内皮素的含量有关。
关键词(KeyWords)： 复方钩藤片;自发性高血压;降压作用;醛固酮;内皮素
基金项目(Foundation): 湖南省自然科学基金重点项目(07JJ3050);; 湖南省科技厅资助项目(2007FJ3006)
作者(Author): 谭元生,王宇红
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