刘昱秀,孙忠人,吴建丽,张宇欣,尹洪娜,魏庆双

• 1:黑龙江中医药大学
• 2:黑龙江中医药大学附属第二医院
• 3:北京中医药大学

摘要(Abstract)：

中医认为缺血性脑卒中属于"偏枯"范畴,其发病与脉络虚损,风邪内侵,阴阳失调,气血无以濡养筋脉密切相关。近年来针刺疗法被广泛用于缺血性脑卒中临床治疗,取得令人满意的效果。本文从周细胞促进微血管新生和调节炎症反应方向着手,归纳与分析周细胞相关机制在针刺治疗脑梗死的研究进展,并对当前研究中存在的一些问题进行探讨。

关键词(KeyWords)： 缺血性脑卒中;针刺;周细胞;血管新生;抗炎;综述

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年项目（81804206）;; 黑龙江省普通本科高等学校青年创新人才培养计划项目（UNPYSCT-2018230）;; 黑龙江中医药大学博士创新基金项目（2018bs06）;; 第66批中国博士后科学基金面上项目（2019M660572）

作者(Author): 刘昱秀,孙忠人,吴建丽,张宇欣,尹洪娜,魏庆双

参考文献(References)：

• [1] Warner JJ,Harrington RA,Sacco RL,et al. Guidelines for the early management of patients with acute ischemic stroke:2019 update to the 2018 guidelines for the early management of acute ischemic stroke[J]. Stroke,2019,50(12):3331-3332.
• [2] Cai W,Liu H,Zhao J,et al. Pericytes in brain injury and repair after ischemic stroke[J]. Transl Stroke Res,2017,8(2):107-121.
• [3] Liao S,Luo C,Cao B,et al. Endothelial progenitor cells for ischemic stroke:Update on basic research and application[J].Stem Cells Int,2017,2017:2193432.
• [4]李韵歆，刘振权，李月，等.缺血性脑卒中神经血管单元的研究进展[J].中华老年心脑血管病杂志，2019,21(2):217-220.
• [5] Hall CN,Reynell C,Gesslein B,et al. Capillary pericytes regulate cerebral blood flow in health and disease[J]. Nature,2014,508(7494):55-60.
• [6]郑德松，董静.针灸通督法联合康复训练对缺血性脑卒中患者平衡功能的影响[J].中国中医急症，2017,26(8):1465-1467.
• [7]杨海峰，彭辉，刘琰.针刺联合康复治疗对急性期缺血性脑卒中患者肢体运动功能障碍的影响[J].陕西中医，2019,40(6):708-710.
• [8] Chavez LM,Huang SS,Macdonald I,et al. Mechanisms of acupuncture therapy in ischemic stroke rehabilitation:A literature review of basic studies[J]. Int J Mol Sci,2017,18(11).
• [9] Zhang Y,Zhang X,Wei Q,et al. Activation of sigma-1 receptor enhanced pericyte survival via the interplay between apoptosis and autophagy:Implications for blood-brain barrier integrity in stroke[J]. Translational stroke research,2019,11(2):267-287.
• [10] Vanlandewijck M,He L,M?e MA,et al. A molecular atlas of cell types and zonation in the brain vasculature[J]. Nature,2018,554(7693):475-480.
• [11] Nakamura K,Arimura K,Nishimura A,et al. Possible involvement of basic FGF in the upregulation of PDGFRbeta in pericytes after ischemic stroke[J]. Brain Res,2016,1630:98-108.
• [12]贾蓝羽，杜元灏，李晶，等.电针“水沟”穴对脑缺血大鼠缺血脑组织血管新生相关因子表达的影响[J].针刺研究，2019,44(10):715-721.
• [13]张荻，徐鸣曙，张英杰，等.脑缺血后周细胞及相关血管生成信号通路的研究进展[J].中国康复理论与实践，2019,25(5):534-539.
• [14] Zhang J,Kasim V,Xie YD,et al. Inhibition of PHD3 by salidroside promotes neovascularization through cell-cell communications mediated by muscle-secreted angiogenic factors[J]. Sci Rep,2017,7:43935.
• [15]鲁亦斌.电针对脑缺血再灌注大鼠脑内PDGF-B及TGF-β1影响的研究[D].武汉：湖北中医学院，2009.
• [16]桑鹏，王顺，赵佳辉.不同经穴针刺对脑卒中偏瘫痉挛大鼠脑组织PDGF-B、PDGFR-β表达的影响[J].中国中医药科技，2012,19(6):524-525.
• [17] Gaceb A，?zen I,Padel T,et al. Pericytes secrete pro-regenerative molecules in response to platelet-derived growth factor-BB[J]. Journal of cerebral blood flow and metabolism:official journal of the International Society of Cerebral Blood Flow and Metabolism,2018,38(1):45-57.
• [18] Shen J,Xu G,Zhu R,et al. PDGFR-βrestores blood-brain barrier functions in a mouse model of focal cerebral ischemia[J]. Journal of cerebral blood flow and metabolism:official journal of the International Society of Cerebral Blood Flow and Metabolism,2019,39(8):1501-1515.
• [19]李钦潘，韩永升，韩咏竹，等.“醒脑开窍”针刺法对脑缺血再灌注大鼠模型早期脑内血管内皮生长因子与胶质纤维酸性蛋白表达的影响[J].中国康复医学杂志，2015,30(7):645-650.
• [20]穆桂萍，曾瑶池，陈鹏典，等.针刺任督脉对脑缺血再灌注大鼠血管内皮生长因子和CD34表达的影响[J].中国医药导报，2013,10(25):18-19,22.
• [21] Tae-Yun K,Federico B,Kumar JM,et al. Pericytes enable effective angiogenesis in the presence of proinflammatory signals[J]. Proceedings of the National Academy of Sciences of the United States of America,2019,116(47).
• [22]关莹.针康法对缺血性卒中后认知障碍非痴呆患者BOLD-fMRI及血清生物标志物的影响[D].哈尔滨：黑龙江中医药大学，2019.
• [23] Kang TY,Bocci F,Jolly MK,et al. Pericytes enable effective angiogenesis in the presence of proinflammatory signals[J].Proceedings of the National Academy of Sciences of the United States of America,2019,116(47):23551-23561.
• [24] Shen J,Xu G,Zhu R,et al. PDGFR-beta restores bloodbrain barrier functions in a mouse model of focal cerebral ischemia[J]. J Cereb Blood Flow Metab,2019,39(8):1501-1515.
• [25] Armulik A,Mae M,Betsholtz C. Pericytes and the bloodbrain barrier:recent advances and implications for the delivery of CNS therapy[J]. Ther Deliv,2011,2(4):419-422.
• [26]秦彦强，孙忠人，张亚娟，等.针刺预处理对脑梗死大鼠细胞凋亡及炎性因子的影响[J].中国中医急症，2015,24(4):565-568,575.
• [27]郝磊，刘磊，董岸莺，等.大鼠缺血再灌注损伤脑内骨髓间充质干细胞移植抑制TNF-α表达的上调促进TGFβ1表达的上调[J].中国组织化学与细胞化学杂志，2017,26(4):
• [28] 3R2u7s-te3n3h5o.ven J,Aalderink M,Scotter EL,et al. TGF-beta1regulates human brain pericyte inflammatory processes involved in neurovasculature function[J]. J Neuroinflammation,2016,13:37.
• [29]孙琳琳.电针对脑缺血再灌注模型大鼠炎性反应相关信号的影响及机制研究[D].北京：北京中医药大学，2013.
• [30]胡英华，王燕，蒋雪玲，等.电针头穴早期干预对急性缺血性脑卒中（气虚血瘀证）患者炎性因子和血液流变学指标的影响[J].中国中医急症，2017,26(11):2040-2042.
• [31] Xing Y,Zhang M,Li WB,et al. Mechanisms involved in the neuroprotection of electroacupuncture therapy for ischemic stroke[J]. Front Neurosci,2018,12:929.
• [32] Kang KA,Shin ES,Hur J,et al. Acupuncture attenuates neuronal cell death in middle cerebral artery occlusion model of focal ischemia[J]. Neurol Res,2010,32(S1):84-87.
• [33]宁文华，李礼，郭扬，等.电针预处理脑保护作用机制研究进展[J].中国康复理论与实践，2019,25(11):1315-1319.