中药调控肠道菌群治疗腹泻型肠易激综合征的研究进展
王洋洋,陈楚,郑烈,马芳,李俏飞,闻新丽
摘要(Abstract):
腹泻型肠易激综合征(IBS-D)系指以腹痛、腹泻等腹部不适症状为主的一种功能性肠病。研究表明,IBS-D的发生与肠道菌群失衡密切相关;与此同时,大量研究证实中药有效成分可通过改变肠道黏膜结构、加强肠道黏膜屏障、促进机体代谢等方式,改善肠道微生态环境,尤其在治疗IBS-D中作用显著。故本研究通过查阅临床资料并检索相关文献,总结单味中药、复方制剂和中药提取物以肠道菌群为靶点治疗IBS-D的疗效,为进一步临床研究提供参考依据。
关键词(KeyWords): 腹泻型肠易激综合征;中药;肠道菌群;代谢产物;肠道微生态失衡;综述
基金项目(Foundation): 国家重点研发计划“中医药现代化研究”专项(2018YFC1705402);; 陕西省中医药管理局科研项目(2019-ZZJC0010);; 陕西省中医医院博士启动基金教育培养计划(2022)
作者(Author): 王洋洋,陈楚,郑烈,马芳,李俏飞,闻新丽
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