杜若桑,苑鸿雯,郑淑美,王宝华,崔海

• 1:首都医科大学

摘要(Abstract)：

目的观察针刺对创伤性脑损伤(TBI)大鼠血清胶质纤维酸性蛋白(GFAP)和S-100B蛋白水平的影响,评估针刺对创伤性脑损伤的疗效。方法按随机数字表法随机将120只雄性SD大鼠随机分成3组,每组40只:假手术组、模型组、针刺组。假手术组只开骨窗,不进行模型制备;模型组和针刺组制备TBI模型;针刺组造模后即接受针刺治疗,每日1次。术后6 h、1 d、3 d、5 d 4个时间点每组均随机选出10只大鼠进行血清GFAP、S-100B蛋白水平和改良的神经功能缺损(m NSS)评分观察与检测。结果相较假手术组,模型组6 h即检测到血清GFAP和S-100B蛋白水平升高(P<0.01)。伤后6 h、1 d检测发现针刺组GFAP水平比同期模型组降低(P<0.05),伤后6 h、1 d、3 d检测发现针刺组S-100B蛋白水平比同期模型组显著降低(P<0.01)。4个检测时间点上,模型组大鼠m NSS评分均高于同期假手术组(P<0.01),针刺组评分显著低于同期模型组(P<0.05或P<0.01)。结论 TBI早期采用针刺干预可明显减轻大鼠脑损伤的程度。

关键词(KeyWords)： 创伤性脑损伤;针刺;GFAP;S-100B蛋白;mNSS评分

Abstract:

Keywords:

基金项目(Foundation): 首都医科大学科研基金项目(自然科学类)(17ZR26)

作者(Author): 杜若桑,苑鸿雯,郑淑美,王宝华,崔海

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