姜黄素对癫痫幼鼠学习记忆及神经元凋亡的影响Effects of Curcumin on Learning and Memory and Neuron Apoptosis in Epileptic Immature Rats
廖婕,梅燕
摘要(Abstract)：
目的观察姜黄素对癫痫幼鼠的学习记忆及海马组织神经元凋亡的影响并探讨其机制。方法将50只21 d龄的SD幼鼠随机分正常组,模型组,姜黄素高(100 mg/kg)、姜黄素中(50 mg/kg)、姜黄素低(25 mg/kg)剂量组,姜黄素各组给予相应剂量姜黄素灌胃,连续2周。Morris水迷宫法检测乳鼠学习记忆能力、TUNEL法检测乳鼠海马神经元的凋亡、Western blotting法检测Cleaved-caspase-3蛋白的表达情况。结果与模型组大鼠比较,姜黄素高、中、低剂量组的学习记忆能力显著提高(P<0.01);细胞凋亡情况显著改善(P<0.01);且Cleaved-caspase-3蛋白的表达显著降低(P<0.01)。结论姜黄素可能通过抑制Cleaved-caspase-3蛋白的表达,从而抑制癫痫幼鼠海马神经元的凋亡。
关键词(KeyWords)： 姜黄素;癫痫;神经元;凋亡
基金项目(Foundation): 重庆市基本科研业务费资助项目(CSTC-jbky-01717)
作者(Author): 廖婕,梅燕
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