温法在晚期肿瘤患者阿片相关性谵妄中应用之辨析
李欣荣
摘要(Abstract):
阳气不足、痰瘀药毒凝滞脑气是晚期癌瘤患者阿片类药物相关性谵妄的重要病机。本文拟通过对上述机理阐释结合病理药理机制,提出以温法为基础的治疗方法是治疗此类疾病的新思路。
关键词(KeyWords): 温法;癌瘤;阿片;谵妄
基金项目(Foundation):
作者(Author): 李欣荣
参考文献(References):
- [1]Voyer P,Richard S,Doucet L,et al.Factors associated with delirium severity among older persons with dementia[J].Journal of Neuroscience Nursing,2011,43(2):62-69.
- [2]Tanaka R,Ishikawa H,Sato T,et al.Incidence of delirium among patients having cancer injected with different opioids for the first time[J].Am J Hosp Palliat Care,2016,34(6):572-576.
- [3]Senel G,N Uysal,G Oguz,et al.Delirium frequency and risk factors among patients with cancer in palliative care unit[J].American Journal of Hospice&Palliative Care,2017,34(3):282-286.
- [4]Bowen JD,Larson EB.Drug-induced cognitive impairment.Defining the problem and finding solutions[J].Drugs&Aging,1993,3(4):349-357.
- [5]Maldonado JR.Acute brain failure:pathophysiology,diagnosis,management,and sequelae of delirium[J].Critical Care Clinics,2017,33(3):461-519.
- [6]Devoto P,Flore G,Pira L,et al.Co-release of noradrenaline and dopamine in the prefrontal cortex after acute morphine and during morphine withdrawal[J].Psychopharmacology,2002,160(2):220-224.
- [7]Cerejeira J,Lagarto L,Mukaetovaladinska EB.The immunology of delirium[J].Neuroimmunomodulation,2014,21(3):72-78.
- [8]Skaug OE.Postopertiva delirium.A stress reaction due to cerebral tryptophan deficiency report of a case successfully treated with tryptophan[J].Tidsskrift for Den Norske Lgeforening Tidsskrift for Praktisk Medicin Ny Rkke,1984,104(2):97-98.
- [9]Maldonado JR.Neuropathogenesis of delirium:review of current etiologic theories and common pathways[J].American Journal of Geriatric Psychiatry Official Journal of the American Association for Geriatric Psychiatry,2013,21(12):1190-1222.
- [10]刘菊妍,杨钦河,吕志平,等.慢性阿片类耐受、戒断状态下下丘脑-垂体-性腺轴改变及温阳益气活血复方作用的临床与实验研究[J].中华中医药杂志,2001,16(1):28-32,82.
- [11]陈晓燕.桃仁、桑叶化学成分及生物活性研究[D].北京:北京协和医学院,2014.
- [12]李海峰,石若娜,韩文静,等.石菖蒲药理作用及其机制的研究进展[J].时珍国医国药,2016,27(11):2728-2730.
- [13]胡竟一,雷玲,余悦,等.连翘的抗炎解热作用研究[J].中药药理与临床,2007,23(3):51-52.
- [14]许源,宿树兰,王团结,等.桂枝的化学成分与药理活性研究进展[J].中药材,2013,36(4):674-678.
- [15]孙森凤,姜雪,张颖颖.附子药理作用研究进展[J].山东化工,2017,46(11):65-67.
- [16]邱慧彬,孙涛,金博.精神心理因素与功能性胃肠疾病的研究进展[J].医学综述,2011,17(14):2143-2145.
- [17]Todd OM,Gelrich L,Mac Lullich AM,et al.Sleep disruption at home as an independent risk factor for postoperative delirium[J].Journal of the American Geriatrics Society,2017,65(5):949-957.
- [18]Flannery AH,Oyler DR,Weinhouse GL.The impact of interventions to improve sleep on delirium in the ICU:a systematic review and research framework[J].Critical Care Medicine,2016,44(12):2231-2240.
- [19]沈自尹,蔡定芳,张玲娟,等.补肾和健脾对免疫系统不同作用方式的研究[J].中国中西医结合杂志,1997,17(6):351-353.
- [20]童瑶,邹军,倪力强,等.化痰、温阳法对慢性应激大鼠IL-1β、IL-2及下丘脑CRH m RNA、垂体ACTH m RNA基因表达的影响[J].中国中医基础医学杂志,2005,11(7):501-502,510.
- [21]肖骋,肖劲松,李华钢,等.奥氮平和氟哌啶醇治疗谵妄的Meta分析[J].武汉大学学报:医学版,2015,36(5):839-844.