电针针刺足三里治疗复苏后综合征患者的临床研究Clinical Observation of Electroacupuncture at Zusanli(ST 36) on Patients with Post Resuscitation Syndrome
曾瑞峰,丁邦晗,赖芳,段云彪,李尊江,李俊
摘要(Abstract):
目的评价电针针刺足三里穴对复苏后综合征患者神经功能以及预后的影响。方法回顾2013年6月到2017年12月在广东省中医院院内、院外发生心脏骤停,恢复自主循环后转至ICU诊治的病例,根据实施电针针刺足三里与否将患者分为电针组和对照组。通过观察两组复苏成功后第1、3、5、7、14日相关指标变化,对比电针针刺足三里对复苏后综合征患者的神经功能及预后的影响。结果在重度脑功能损伤患者中,心源性心脏骤停患者针刺组与对照组的ROSC后第3日的GCS评分的比较差异存在统计学意义(P<0.05);非心源性心脏骤停患者针刺组与对照组的GCS评分在第5、7、14日差异存在统计学意义(P<0.05);心源性心脏骤停患者中两组第14日的APACHEⅡ评分以及非心源性心脏骤停患者中两组第5、7、14日的APACHEⅡ评分存在统计学差异(P<0.05);非心源性心脏骤停患者中,针刺组与对照组的14 d生存率存在明显差异(P<0.05),其余比较差异无统计学意义(P>0.05)。在中度脑功能损伤患者中,所有对比均无明显差异(P>0.05)。结论早期应用电针针刺足三里穴能改善复苏后患者神经功能和预后,尤其对非心源性心脏骤停的PRS患者,疗效更佳。
关键词(KeyWords): 复苏后综合征;心肺复苏;神经功能恢复;电针;足三里穴
基金项目(Foundation): 国家卫生计生委公益性行业科研专项项目(201502019);; 广东省科技厅项目(2017ZC0164,2017ZC0160)
作者(Author): 曾瑞峰,丁邦晗,赖芳,段云彪,李尊江,李俊
参考文献(References):
- [1]Servadei F,Nasi MT,Cremonini AM,et al.Importance of a reliable admission Glasgow Coma Scale score for determining the need for evacuation of posttraumatic subdural hematomas:a prospective study of 65 patients[J].J Trauma,1998,44(5):868-873.
- [2]Shao F,Li CS,Liang LR,et al.Outcome of out-of-hospital cardiac arrests in Beijing,China[J].Resuscitation,2014,85(11):1411-1417.
- [3]曾瑞峰,刘相圻,丁邦晗,等.中医学救治心肺脑复苏现状与展望[J].中国中医急症,2017,26(8):1409-1412.
- [4]Chen SH,Sun H,Zhang YM,et al.Effects of acupuncture at Baihui(GV 20)and Zusanli(ST 36)on peripheral serum expression of Micro RNA 124,laminin and integrin beta1 in rats with cerebral ischemia reperfusion injury[J].Chin J Integr Med,2016,22(1):49-55.
- [5]Tian WQ,Peng YG,Cui SY,et al.Effects of electroacupuncture of different intensities on energy metabolism of mitochondria of brain cells in rats with cerebral ischemia-reperfusion injury[J].Chin J Integr Med,2015,21(8):618-623.
- [6]祁岩超,刘振寰,柴铁劬,等.针刺抑制幼鼠HIBD脑组织神经细胞凋亡的实验研究[J].中国实用神经疾病杂志,2011,14(15):1-4.
- [7]陈鑫,严晓铭,柯开富.APACHEⅡ与GCS评分预测神经重症监护患者病死率的价值[J].江苏医药,2014,40(4):444-446.
- [8]Vargas M,Servillo G,Sutherasan Y,et al.Effects of in-hospital low targeted temperature after out of hospital cardiac arrest:A systematic review with meta-analysis of randomized clinical trials[J].Resuscitation,2015,91:8-18.
- [9]Arrich J,Holzer M,Havel C,et al.Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation[J].Cochrane Database Syst Rev,2016,2:D4128.
- [10]Kim H,Koo YS,Shin MJ,et al.Combination of constraint-induced movement therapy with electroacupuncture improves functional recovery following neonatal hypoxic-ischemic brain injury in rats[J].Biomed Res Int,2018,2018:8638294.
- [11]丁见,吴锋,缪化春,等.电针对脑缺血大鼠丘脑腹后外侧核神经生长因子和生长休止特定蛋白7表达的影响[J].针刺研究,2017,42(2):125-130.
- [12]Liang S,Lin Y,Lin B,et al.Resting-state functional magnetic resonance imaging analysis of brain functional activity in rats with ischemic stroke treated by electro-acupuncture[J].J Stroke Cerebrovasc Dis,2017,26(9):1953-1959.
- [13]楚海波,张双勇,付俊丽,等.帖氏飞针法治疗急性脑梗死偏瘫:随机对照研究[J].中国针灸,2017,37(11):1153-1156.
- [14]赵磊,张丽丽,包华,等.不同药物穴位注射治疗急性缺血性脑卒中的临床研究[J].针刺研究,2016,41(4):347-350.
- [15]Zhou F,Guo J,Cheng J,et al.Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury:dependence on stimulation intensity and frequency[J].J Appl Physiol(1985),2011,111(6):1877-1887.
- [16]Wan Q,Pan P,Xu C,et al.Effects of electroacupuncture preconditioning on jugular vein glucose level and cerebral edema in rats undergoing cerebral ischemia reperfusion that induced injury[J].Int J Clin Exp Med,2014,7(11):4384-4388.
- [17]尹岭,金香兰,乔卫安,等.针刺足三里PET脑功能成像[J].中国针灸,2003,23(1):27-28.
- [18]Zhu X,Yin J,Li L,et al.Electroacupuncture preconditioninginduced neuroprotection may be mediated by glutamate transporter type 2[J].Neurochem Int,2013,63(4):302-308.
- [19]Ferreira AS,Lima JG,Ferreira TP,et al.Prophylactic effects of short-term acupuncture on Zusanli(ST36)in Wistar rats with lipopolysaccharide-induced acute lung injury[J].Zhong Xi Yi Jie He Xue Bao,2009,7(10):969-975.
- [20]乐林莉,宋学敏,张宗泽,等.电针足三里穴对烫伤后脓毒症大鼠急性肺损伤的影响[J].中华麻醉学杂志,2014,34(1):85-89.
- [21]Huang CL,Huang CJ,Tsai PS,et al.Acupuncture stimulation of ST-36(Zusanli)significantly mitigates acute lung injury in lipopolysaccharide-stimulated rats[J].Acta Anaesthesiol Scand,2006,50(6):722-730.
- [22]Torres-Rosas R,Yehia G,Pena G,et al.Dopamine mediates vagal modulation of the immune system by electroacupuncture[J].Nat Med,2014,20(3):291-295.