王琳,吴建鹏,余旭超,王丽

• 1:陕西省西安市中医医院

摘要(Abstract)：

目的 观察安宫牛黄丸治疗脓毒症相关性脑病(SAE)患者的临床疗效。方法 将重症监护室(ICU SAE患者90例采用随机数字表法分对照组与治疗组各45例。对照组患者予以西医常规治疗，治疗组患者在对照组基础上加安宫牛黄丸，温水溶开后鼻胃管注入，两组疗程均为5 d。比较两组患者治疗结束后临床疗效；检测两组患者治疗前后血清神经元特异性烯醇化酶(NSE)、S100钙结合蛋白(S-100β)、C型利钠肽及其氨基末端前肽(NT-proCNP)水平及血浆降钙素原(PCT)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。结果 治疗后，两组患者中医证候评分均下降，治疗组下降更显著(P<0.01)；两组患者格拉斯哥昏迷量表(GCS)评分均升高，治疗组升高更显著(P<0.01)；两组患者血清NSE、S-100β、NT-proCNP、PCT、IL-6、TNF-α水平均下降，治疗组下降更显著(P<0.05)。结论 安宫牛黄丸可显著减轻SAE患者炎症反应，下调血清NSE、S-100β、NT-proCNP水平，保护SAE患者神经功能，临床应用效果显著。

关键词(KeyWords)： 脓毒症相关性脑病;安宫牛黄丸;脑损伤;炎症因子

Abstract:

Keywords:

基金项目(Foundation): 陕西省自然科学基金项目(2022JQ-848);; 陕西省重点研发计划项目(S2021-YF-YBSF-0796);; 西安市卫生健康委员会中医药科研项目(SZL201938)

作者(Author): 王琳,吴建鹏,余旭超,王丽

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