冯俊,李树生,陈华文

• 1:华中科技大学同济医学院附属同济医院

摘要(Abstract)：

目的丹参酮ⅡA对压力超负荷心肌肥厚大鼠交感神经重构的影响。方法将40只大鼠随机分为模型组(TAC)和假手术组(Sham),每组均随机给予丹参酮ⅡA(TanⅡA)或生理盐水(Saline)处理,观察连续治疗12周后的左心室的生长相关蛋白43(GAP43)、酪氨酸羟化酶(TH)蛋白、神经生长因子(NGF)表达水平、GAP43和TH阳性神经纤维密度。结果与Sham+Saline组相比,TAC处理可导致左心室的TH、GAP43及NGF的蛋白水平上升,且GAP43和TH阳性神经纤维密度均上升;Tan ⅡA可有效地改善TAC的症状;TanⅡA对Sham组的各项指标没有影响。结论压力超负荷心肌肥厚大鼠的交感神经发生重构,采用TanⅡA可改善心肌交感神经重构。

关键词(KeyWords)： 丹参酮ⅡA;压力超负荷;交感神经重构;心肌肥厚

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助课题(No.81202825);; 湖北省自然科学基金资助课题(2012FFB02410)

作者(Author): 冯俊,李树生,陈华文

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