血脂康对高脂血症大鼠脂联素、瘦素及炎症因子的影响
吴冬梅,潘涛,施广飞
摘要(Abstract)：
目的观察血脂康对高脂血症大鼠的疗效,通过观察治疗前后脂联素、瘦素及炎症因子C反应蛋白(CRP)、白细胞介素(IL-6)变化,探讨其保护内皮、抗动脉粥样硬化的机制。方法实验用清洁级SD大鼠随机分为3组,每组12只。正常组饲喂普通饲料,余各组饲喂高脂饲料。高脂血症大鼠造模成功后,正常组灌胃纯净水2mL,1次/d;模型组灌胃纯净水2mL,1次/d;血脂康组灌胃血脂康1000mg/(kg.d),2mL,1次/d。观察6周后血脂、脂联素、瘦素水平及CRP、IL-6的变化。结果治疗6周后,血脂康组总胆固醇、低密度脂蛋白、胆固醇、脂联素、瘦素、CRP、IL-6较治疗前有显著差异(P<0.05),模型组前后无显著差异(P>0.05)。结论血脂康具有明确的调脂、增加抗炎因子、降低炎症因子的作用。
关键词(KeyWords)： 脂联素;瘦素;C反应蛋白;白细胞介素6;血脂康
基金项目(Foundation):
作者(Author): 吴冬梅,潘涛,施广飞
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