中药干预应激防治冠心病的可行性分析Feasibility Study of Stress Intervention in Chinese Herbal Treatment on Cardiovascular Disease
田盈,朱金墙,刘辉,杨冰,刘东林,张晗
摘要(Abstract):
本文简述了应激的概念与特点,综合分析了急慢性应激对冠心病发生、发展的影响机制以及冠心病引起的应激负荷升高,并参考目前抗应激损伤基础研究,对有稳定应激、抗应激损伤作用的单味药及提取物、中药复方进行初步筛选,以期为冠心病临床用药和中药研发提供新的思路。
关键词(KeyWords): 应激;冠心病;中药干预;可行性分析
基金项目(Foundation): 国家自然科学基金课题(81001660);; 教育部科学技术重点研究项目(212006)
作者(Author): 田盈,朱金墙,刘辉,杨冰,刘东林,张晗
参考文献(References):
- [1]JM Koolhaas,A Bartolomucci,B Buwalda,et al.Stress revisited:A critical evaluation of the stress concept[J].Neuroscience&Biobehavioral Reviews,2011,35:(5):1291-1301.
- [2]钱令嘉.应激与应激医学[J].疾病控制杂志,2003,7(5):393-396.
- [3]杨炳炘.香山科学会议第420-424次学术讨论会简述[J].中国基础科学,2012,14(4):22-29.
- [4]Stojanovich L,Marisavljevich D.Stress as a trigger of autoimmune disease[J].Autoimmunity Reviews,2008,7(3):209-213.
- [5]Saner H.Stress as a cardiovascular risk factor[J].Therapeutische Umschau,2005,62(9):597-602.
- [6]Andrew Stepoe,Mika Kibimaki.Stress and Cardiovascular Disease[J].Nature Review Cardiology,2012,9(6):360-370.
- [7]Roland von Kanel.Psychosocial stress and cardiovascular risk:current opinion[J].Swiss Medical Weekly,2012,142:w13502.
- [8]S Yusuf,S Hawken,S unpuu,et al.Effect of potentially modifiable risk factors associated with myocardial infarction in 52countries:case control study[J].The Lancet,2004,364(9438):937-952.
- [9]Sheldon Cohen,Denise Janicki-Deverts,William J.Doyle,et al.Chronic stress,glucocorticoid receptor resistance in flammation,and disease risk[J].European Journal of Gastroenterololgy Hepatology,2013,109(16):5995-5999.
- [10]张志清,刘晓华,杨志华,等.应激适应建立对应激大鼠心肌的保护作用[J].现代预防医学,2009,36(1):161-163.
- [11]刘梅颜,胡大一.抑郁症与缺血性心脏病[J].中国医药导刊,2005,7(4):271-274.
- [12]Volker Scheid.Depression,Constraint,and the Liver:(Dis)assembling the treatment of emotion-related disorders in Chinese medicine[J].Culture Medicine and Psychiatry,2013,37(1):30-58.
- [13]毛浩萍,高秀梅,赵粉荣,等.开窍中药对牛肾上腺髓质细胞分泌的影响[J].中国药学杂志,2008,43(20):1555-1558.
- [14]Haixia Dang,Lihua Sun,Xinmin Liu,et al.Preventive action of Kai Xin San aqueous extract on depressive-like symptoms and cognition deficit induced by chronic mild stress[J].Experimental Biology and Medicine,2009,234:785-793.
- [15]Xiaoxia Gao,Xingyu Zheng,Zhenyu Li,et al.Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry[J].Journal of Ethnopharmacology,2011,137(1):690-699.