肖福龙,宫丽鸿,姜丹

• 1:辽宁中医药大学
• 2:辽宁中医药大学附属医院

摘要(Abstract)：

目的观察搜风祛痰中药对大鼠心肌缺血再灌注模型冠脉微循环内皮障碍的影响。方法健康SPF级SD大鼠140只,随机分成假手术组、模型组、培哚普利组、搜风祛痰中药组,每组35只。假手术组只穿线不结扎,其余3组建立缺血再灌注模型。预先给予相应药物干预后造模,心电图评价造模情况。RT-PCR法测定各组大鼠血栓调节蛋白(TM)、内皮细胞蛋白C受体(EPCR) mRNA表达水平,ELISA法检测各组大鼠血清前列环素(PGI2)、血栓素A2(TXA2)含量。结果心电图显示造模成功。与模型组相比,搜风祛痰中药组PGI2含量升高、TXA2含量降低,TM、EPCR mRNA表达水平降低(P <0.05)。结论搜风祛痰中药可保护缺血再灌注大鼠冠脉微循环内皮屏障功能,其机制可能与降低EPCR、TM mRNA表达水平,调节PGI2和TXA2含量相关。

关键词(KeyWords)： 冠脉微循环障碍;心肌缺血再灌注;搜风祛痰中药;内皮屏障;大鼠

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 肖福龙,宫丽鸿,姜丹

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