潘勇军,方邦江,俞志刚,王佑华,曹敏

• 1:鄂东医疗集团市中医医院
• 2:上海中医药大学附属龙华医院

摘要(Abstract)：

目的观察黄芪保心汤对冠状动脉结扎大鼠的血流动力学、凋亡及Bax、Bcl-2,Caspase-3蛋白表达的影响。方法雄性SD大鼠48只,随机分为空白组、假手术组、模型组、黄芪保心汤组,除空白组、假手术组外,结扎冠状动脉造成大鼠心肌缺血损伤模型,假手术组只开胸不结扎,各组予相应药物干预4周后,观察黄芪保心汤对冠状动脉结扎大鼠心肌缺血血流动力学、左室质量指数、心肌细胞凋亡以及Bax、Bcl-2,Caspase-3蛋白表达。结果黄芪保心汤能改善心肌缺血大鼠血流动力学、减少凋亡、降低Bax、Caspase-3水平,升高Bcl-2水平,具有显著差异(P<0.05或P<0.01)。结论黄芪保心汤具有良好的抗心肌缺血作用,其作用机理与减轻心肌细胞凋亡,降低Bax、Caspase-3表达,升高Bcl-2表达相关。

关键词(KeyWords)： 黄芪保心汤;血流动力学;凋亡

Abstract:

Keywords:

基金项目(Foundation): 上海中医药大学中西医结合高原学科面上项目

作者(Author): 潘勇军,方邦江,俞志刚,王佑华,曹敏

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