调脂通脉中药对动脉粥样硬化兔模型内皮细胞标志物的影响
张璐,孙晴,郭书文,郑敏,苏兆铎,武建功,刘文臣,陈曦
摘要(Abstract)：
目的观察动脉粥样硬化兔模型内皮细胞标志物的变化及调脂通脉中药的干预作用。方法采用高脂饲料饮食和球囊损伤颈动脉的方法复制动脉粥样硬化兔模型,随机分为正常组、模型组、假手术组、西药组(阿托伐他汀,1.1 mg/kg)和中药组(调脂通脉中药,7.3 g/kg)组,共5组,选择治疗后第6周、12周为观察点。在两个时间点,检测血脂水平;HE染色检测颈总动脉、肝脏形态学变化;ELISA检测内皮细胞标志物内皮素(ET-1)、一氧化氮合酶(e NOS)、前列环素2(PGI2)、血栓素A2(TXA2)的变化。结果两个时间点,模型组ET-1、TXA2表达增加(P<0.05)、e NOS、PGI2表达下降(P<0.05)。调脂通脉中药能够降低ET-1、TXA2水平(P<0.01),且升高e NOS、PGI2表达(P<0.05)。结论调脂通脉中药能够改善血管内皮细胞损伤,减轻动脉粥样硬化。
关键词(KeyWords)： 动脉粥样硬化;兔;调脂通脉中药;内皮细胞标志物
基金项目(Foundation):
作者(Author): 张璐,孙晴,郭书文,郑敏,苏兆铎,武建功,刘文臣,陈曦
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