黄芩抗菌作用物质基础研究
雷蕾,杨秦予
摘要(Abstract):
目的观察黄芩提取物及分离的化合物的抑菌效果。方法醇提法对黄芩进行提取,对提取物用不同溶剂进行萃取,对萃取物进行分离和纯化,得到了4个化合物并进行结构鉴定,对不同提取物和化合物进行体外抑菌实验。结果黄芩乙酸乙酯和正丁醇提取物在质量浓度为1 mg/m L时对大肠杆菌有一定的抑菌作用,千纸层素-A和黄芩素对大肠杆菌也有一定的抑菌作用。结论千纸层素-A和黄芩素是黄芩抗菌作用的物质基础之一。
关键词(KeyWords): 黄芩;抗菌;黄芩素;千纸层素-A
基金项目(Foundation):
作者(Author): 雷蕾,杨秦予
参考文献(References):
- [1]肖丽和,王红燕,宋少江,等.滇黄芩化学成分的分离与鉴定[J].沈阳药科大学学报,2003,20(3):181-183.
- [2]徐丹洋,陈佩东,张丽,等.黄芩的化学成分研究[J].中国实验方剂学杂志,2011,17(1):78-80.
- [3]Takagi S,Yamuki M,Inoue K.Studies on the water-soluble constituents of the roots of Scutellaria baicalensis Georgi(wogon)[J].Yakugaku Zasshi,1980,100:1220-1220.
- [4]李云霞,索全伶,贺文智,等.黄芩素的分离纯化与结构表征[J].光谱学与光谱分析,2008,28(8):1895-1899.
- [5]Xiaofei Shang,Xirui He,Xiaoying He,et al.The genus Scutellaria an ethnopharmacological and phytochemical review[J].Journal of Ethnopharmacology,2010,128:279-313.
- [6]Xiaofei Shang,Xirui He,Xiaoying He,et al.The genus Scutellaria an ethnopharmacological and phytochemical review[J].Journal of Ethnopharmacology,2010,128:279-313.
- [7]Ma SC,Du J,But PPH,et al.Antiviral Chinese medicinal herbs against respiratory syncytial virus[J].Journal of Ethnopharmacology,2002,79:205-211.
- [8]Gousiadou C,Karioti A,Heilmann J,et al.Iridoids from Scutellaria albida ssp.Albida[J].Phytochemistry,2007,68:1799-1804.
- [9]Kumagai T,M’’uller CI,Desmond JC,et al.Scutellaria baicalensis,a herbalmedicine:anti-proliferative and apoptotic activity against acute lymphocytic leukemia[J].Lymphoma and Myeloma Cell Lines,2007,31:523-530.
- [10]Blaszczyk T,Krzyzanowska J,Lamer-Zarawska E.Screening for antimycotic properties of 56 traditional Chinese drugs[J].Phytotherapy Research,2000,14:210-212.
- [11]Schinella GR,Tournier HA,Prieto JM,et al.Antioxidant activity of anti-in ammatory plant extracts[J].Life Sciences,2002,70:1023-1033.