胡国恒,胡哲,盛望,陈励竞

• 1:湖南中医药大学第一附属医院
• 2:湖南省湘潭市中心医院

摘要(Abstract)：

目的观察益气活血方对急性心肌梗死后大鼠缺血心肌组织血管新生和对促血管新生因子肝细胞生长因子(HGF)蛋白表达的影响。方法建立心梗模型后,32只雄性SD大鼠,随机分为假手术组,模型组,麝香保心丸组,益气活血方组4组,用免疫组织化学法检测缺血心肌微血管计数(MVC)和微血管密度(MVD)及缺血心肌HGF蛋白表达。结果益气活血方组心肌梗死范围小于模型组(P<0.05)。益气活血方组、麝香保心丸组的微血管密度均高于模型组(P<0.05)。益气活血方组、麝香保心丸组的HGF蛋白表达较其余组显著升高(P<0.05);益气活血方组与麝香保心丸组的HGF蛋白表达差异无统计学意义(P>0.05)。结论益气活血方能明显减小大鼠心肌梗死面积、促进缺血心肌血管新生,可能与其促进HGF表达有关。

关键词(KeyWords)： 益气活血;血管新生;肝细胞生长因子

Abstract:

Keywords:

基金项目(Foundation): 湖南省科技厅科研课题(2007SK3099)

作者(Author): 胡国恒,胡哲,盛望,陈励竞

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