黄汉超,黄琳,吴永刚,黄雪君,杜铁良

• 1:广东省第二中医院

摘要(Abstract)：

目的探讨六君丹参颗粒为代表的健脾活血法对高血压并动脉硬化大鼠心血管重塑的干预作用。方法选8周龄大鼠50只,分为实验组和对照组,每4周每组处死8只大鼠,进行心脏、动脉切片送病理检查;抽血查基质金属蛋白酶-2、9,谷丙转氨酶,谷草转氨酶等项目。结果治疗组大鼠动脉收缩压有一定程度的下降,病检显示动脉中膜厚度有明显回缩,管腔面积/管壁面积(LA/WA)显示出有意义的提高,电镜显示心肌纤维排列顺序有改善,对线粒体有修复作用;血清基质金属蛋白酶-2、9相比两组差异无统计学意义。结论六君丹参颗粒对逆转心血管重构有明显干预作用,使用安全。

关键词(KeyWords)： 六君丹参颗粒;血管重塑;自发性高血压大鼠;基质金属蛋白酶-2;基质金属蛋白酶-9

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基金项目(Foundation): 广东省自然科学基金课题(2008B060600071)

作者(Author): 黄汉超,黄琳,吴永刚,黄雪君,杜铁良

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