宋长满;史宝娜;董毅;

• 1:大连大学附属新华医院
• 2:辽宁省大连市皮肤病医院

摘要(Abstract)：

目的观察自拟黄芩正气汤联合微生态制剂治疗急性感染性腹泻(湿蕴脾胃证)的临床疗效并探讨其作用机制。方法 92例患者按随机数字表法分为对照组与观察组两组各46例。对照组予常规治疗加微生态制剂治疗,观察组在对照组基础上加自拟黄芩正气汤治疗。比较两组临床疗效、证候评分、止泻时间、粪便常规检查结果、血清炎症因子及不良反应发生情况。结果观察组止泻时间短于对照组(P <0.05)。治疗后两组证候评分与治疗前比较均下降,且观察组下降更明显(均P <0.05)。治疗后两组患者粪便镜检白细胞正常率均明显升高,且观察组高于对照组(均P <0.05)。两组治疗前超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平比较差别均不大(均P> 0.05)。两组治疗后患者hs-CRP、TNF-α及IL-6水平与治疗前比较均下降,且观察组均低于对照组(均P <0.05)。对照组未出现明显的不良反应,观察组2例出现(4.35%)皮疹。两组不良反应发生情况比较差别不大(P> 0.05)。结论自拟黄芩正气汤联合微生态制剂治疗湿蕴脾胃型急性感染性腹泻可提高患者临床疗效,降低证候评分、缩短止泻时间、缓解炎症反应且具有较高的安全性。

关键词(KeyWords)： 急性感染性腹泻;湿蕴脾胃;自拟黄芩正气汤;微生态制剂

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 宋长满;史宝娜;董毅;

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