血必净注射液对脓毒症患者凝血功能的影响The Effect of Xuebijing Injection(血必净注射液) on Cruor Function in Sepsis Illness
明自强,俞林明,吕银祥,王黎卫,吕少敏
摘要(Abstract):
目的探讨血必净注射液对脓毒症患者凝血功能的影响。方法60例无凝血功能障碍的脓毒症患者随机分为两组,对照组30例给予常规综合治疗,治疗组30例加用血必净注射液治疗;分别检测两组患者治疗前、治疗第1、3、7日凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FBG)和血小板计数(PLT)。结果治疗组治疗第7日各项检测指标与对照组比较有显著差异。结论血必净注射液对脓毒症患者的凝血功能有保护作用。
关键词(KeyWords): 脓毒症;血必净注射液;凝血功能
基金项目(Foundation):
作者(Author): 明自强,俞林明,吕银祥,王黎卫,吕少敏
参考文献(References):
- 1Bone R C,Balk R A,Cerra FB,etal.Definitions forSepsis and organ failure and guidelines for the use ofinnovative therapies in Sepsis.The A CCP/SCCM Consensus Conference Com m ittee[J].A m erican College of Chest Physician/Society of Critical Care M edicine.Chest,1992,101:1644~1655
- 2Gando S,K am eue T,N anzaki S,et al.Cytokines,soluble throm bom odulin and dissem inated intravascular coagula-tion in patients with system ic inflam m atory response syndrom e[J].Throm b R es,1995,80:519~526
- 3Boerm eester M A,V an Leeuwen PA,Coyle SM,et al.Inter-leukin-1blockade attenuates m ediator release and dysregula-tion ofthe hem ostatic m echanism during hum an Sepsis[J].A rch Surg,1995,160:739~748
- 4G ando S,N anzaki S,K em m otsu0.D issem inated intravascular coagulation and sustained system ic inflam m atory response syn-drom e predict organ dysfunctions after traum a:application of clinical decision analysis[J].A nn Surg,1999,229:121~127
- 5陈得昌,李红江,毛居卫,等.血小板及骨髓象变化在危重病临床监测中的意义[J].中华急诊医学杂志,2002,11(1):40~42
- 6Baglin T.Dissem inated intravascular coagulation:diagnosis and treatm ent[J].Br M ed J,1996,312:683~687
- 7Scherer R U,Spangenberg P.Procoagulant activity in patients with isolated hea d traum e[J].CritCare M ed,1998,26:149~156
- 8曹书华,高红梅,王永强,等.“神农33号”对多器官功能障碍综合征大鼠细胞因子的影响[J].中华急诊医学杂志,2003,12(2):94~96
- 9曹书华,王今达.血必净对感染性多器官功能障碍综合征大鼠组织及内皮损伤保护作用的研究[J].中国危重病急救医学,2002,14(8):489~491
- 10李志军,孙元莹,吴云良,等.血必净注射液防治家兔应激性脏器损伤的研究[J].中国危重病急救医学,2006,18(2):105~108