杨淑芬,潘新

• 1:上海中医药大学附属曙光医院

摘要(Abstract)：

高尿酸血症在临床发病率逐年走高,相关中药治疗的研究成为热点。根据尿酸在体内的代谢途径,将中药或方剂治疗高尿酸血症的作用机制途径分为抑制尿酸生成药物和促进尿酸排泄药物或是两者兼有。抑制尿酸生成主要是于从不同途径对黄嘌呤氧化酶(XOD)的活性产生抑制作用;促进尿酸排泄主要利用下调负责尿酸重吸收的尿酸转运子URAT1、GLU-9的表达或者上调促尿酸排泄的转运子如OAT1、OAT3、ABCG2的表达。本文通过阐述中药单体或方剂降低尿酸的作用及机制的研究进展,分析并拓展临床中药治疗高尿酸血症的思路。

关键词(KeyWords)： 高尿酸血症;中药;黄嘌呤氧化酶;尿酸转运子;综述

Abstract:

Keywords:

基金项目(Foundation): 上海中医药大学高峰高原学科基金(临床人才专项)

作者(Author): 杨淑芬,潘新

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