肖阳春,李岩,王国庆,郭玉红

• 1:北京中医医院顺义医院
• 2:北京中医医院

摘要(Abstract)：

目的观察参附注射液对脓毒症休克患者的预后影响并探讨其机制。方法选择我院ICU收治的71例脓毒症休克患者作为研究对象,随机分为两组,对照组给予常规治疗,治疗组在对照组治疗的基础上给予参附注射液治疗,比较两组患者入组时及24 h后血血乳酸(Lac)、中心静脉血氧饱合度(ScvO_2)、24 h乳酸清除率,尿量、入组当日及48 h急性生理与慢性健康(APACHEⅡ)评分、序贯器官衰竭(SOFA)评分,受损器官数目,入组后6 h、12 h、24 h、48 h多巴酚丁胺及去甲肾上腺素剂量,以及患者ICU平均住院日、28 d病死率。结果治疗组Lac、ScvO_2、尿量、24 h乳酸清除率指标均优于对照组(P<0.05);治疗组6 h、12 h多巴酚丁胺剂量显著少于对照组(P<0.05)。结论在脓毒症休克24 h集束化治疗结合参附注射液治疗可以改善患者的组织灌注水平,但对患者ICU平均住院日及28 d病死率预后影响改善不很明显。

关键词(KeyWords)： 脓毒症;血液动力学;预后;参附注射液

Abstract:

Keywords:

基金项目(Foundation): 中医感染性疾病基础研究北京市重点实验室开放课题项目(2015ZYGR02)

作者(Author): 肖阳春,李岩,王国庆,郭玉红

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