程海波;辇伟奇;谢恬;左国庆;邱敏;蔡明;梁晓;张海波;刘华文;

• 1:中国抗癌协会中西医整合肿瘤专业委员会
• 2:南京中医药大学
• 3:重庆市中医院
• 4:杭州师范大学

摘要(Abstract)：

<正>晚期肿瘤患者非治疗性恶心呕吐（N&V）是指除外特定治疗（化疗、放疗、靶向治疗、免疫治疗、手术）所致的恶心和呕吐，在多数情况下并非单一原因所致，而是多种因素共同导致。目前还没有针对晚期肿瘤患者非治疗性恶心呕吐的“指南”和“共识”。

关键词(KeyWords)：

Abstract:

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基金项目(Foundation):

作者(Authors): 程海波;辇伟奇;谢恬;左国庆;邱敏;蔡明;梁晓;张海波;刘华文;

参考文献(References)：

• [1] Conill C,Verger E,Henríquez I,et al. Symptom prevalence in the last week of life[J]. J Pain Symptom Manage,1997,14(6):328-331.
• [2] Collis E,Mather H. Nausea and vomiting in palliative care[J].BMJ,2015,351:h6249.
• [3] Hardy JR,O′Shea A,White C,et al. The efficacy of haloperidol in the management of nausea and vomiting in patients with cancer[J]. J Pain Symptom Manage,2010,40(1):111-116.
• [4] Nasir SS,Schwartzberg LS. Recent advances in preventing chemotherapy-induced nausea and vomiting[J]. Oncology(Williston Park),2016,30(8):750-762.
• [5] Hesketh PJ,Kris MG,Basch E,et al. Antiemetics:ASCO guideline update[J]. J Clin Oncol,2020,38(24):2782-2797.
• [6] Navari RM,Pywell CM,Le-Rademacher JG,et al. Olanzapine for the Treatment of Advanced Cancer-Related Chronic Nausea and/or Vomiting:A Randomized Pilot Trial[J]. Jama Oncol,2020,6(6):895-899.
• [7] Suzuki M,Komuro K,Ohara K. Olanzapine and betamethasone are effective for the treatment of nausea and vomiting due to metastatic brain tumors of rectal cancer[J]. Case Rep Gastroenterol,2014,8(1):13-17.
• [8] Cangemi DJ,Kuo B. Practical perspectives in the treatment of nausea and vomiting[J]. J Clin Gastroenterol,2019,53(3):170-178.
• [9] Laval G,Rousselot H,Toussaint-Martel S,et al. SALTO:a randomized,multicenter study assessing octreotide LAR in inoperable bowel obstruction[J]. Bull Cancer,2012,99(2):E1-E9.
• [10] Mariani P,Blumberg J,Landau A,et al. Symptomatic treatment with lanreotide microparticles in inoperable bowel obstruction resulting from peritoneal carcinomatosis:a randomized,double-blind,placebo-controlled phaseⅢstudy[J]. J Clin Oncol,2012,30(35):4337-4343.
• [11] Currow DC,Quinn S,Agar M,et al. Double-blind,placebocontrolled,randomized trial of octreotide in malignant bowel obstruction[J]. J Pain Symptom Manage,2015,49(5):814-821.
• [12] Peng X,Wang P,Li S,et al. Randomized clinical trial comparing octreotide and scopolamine butylbromide in symptom control of patients with inoperable bowel obstruction due to advanced ovarian cancer[J]. World J Surg Oncol,2015,13:50.
• [13] Davis M,Hui D,Davies A,et al. Medical management of malignant bowel obstruction in patients with advanced cancer:2021 MASCC guideline update[J]. Support Care Cancer,2021,29(12):8089-8096.
• [14] Currow DC,Quinn S,Agar M,et al. Double-blind,placebocontrolled,randomized trial of octreotide in malignant bowel obstruction[J]. J Pain Symptom Manage,2015,49(5):814-821.
• [15] Mccaffrey N,Asser T,Fazekas B,et al. Health-related quality of life in patients with inoperable malignant bowel obstruction:secondary outcome from a double-blind,parallel,placebo-controlled randomised trial of octreotide[J]. Bmc Cancer,2020,20(1):1050.
• [16] Berger J,Lester P,Rodrigues L. Medical therapy of malignant bowel obstruction with octreotide,Dexamethasone,and metoclopramide[J]. Am J Hosp Palliat Care,2016,33(4):407-410.
• [17] Tuca A,Roca R,Sala C,et al. Efficacy of granisetron in the antiemetic control of nonsurgical intestinal obstruction in advanced cancer:a phaseⅡclinical trial[J]. J Pain Symptom Manage,2009,37(2):259-270.
• [18] Kaneishi K,Kawabata M,Morita T. Olanzapine for the relief of nausea in patients with advanced cancer and incomplete bowel obstruction[J]. J Pain Symptom Manage,2012,44(4):604-607.
• [19] Kaneishi K,Imai K,Nishimura K,et al. Olanzapine versus metoclopramide for treatment of nausea and vomiting in advanced cancer patients with incomplete malignant bowel obstruction[J]. J Palliat Med,2020,23(7):880-881.
• [20] Mercadante S,Ripamonti C,Casuccio A,et al. Comparison of octreotide and hyoscine butylbromide in controlling gastrointestinal symptoms due to malignant inoperable bowel obstruction[J]. Support Care Cancer,2000,8(3):188-191.
• [21] Krouse RS. The international conference on malignant bowel obstruction:a meeting of the minds to advance palliative care research[J]. J Pain Symptom Manage,2007,34(1 Suppl):S1-S6.
• [22] Campora E,Merlini L,Pace M,et al. The incidence of narcotic-induced emesis[J]. J Pain Symptom Manage,1991,6(7):428-430.
• [23] Lehmann KA. Opioids:overview on action,interaction and toxicity[J]. Support Care Cancer,1997,5(6):439-444.
• [24] Glare P,Miller J,Nikolova T,et al. Treating nausea and vomiting in palliative care:a review[J]. Clin Interv Aging,2011,6:243-259.
• [25] Smith HS,Cox LR,Smith BR. Dopamine receptor antagonists[J]. Ann Palliat Med,2012,1(2):137-142.
• [26] Tramèr MR,Walder B. Efficacy and adverse effects of prophylactic antiemetics during patient-controlled analgesia therapy:a quantitative systematic review[J]. Anesth Analg,1999,88(6):1354-1361.
• [27] Moon YE,Joo J,Kim JE,et al. Anti-emetic effect of ondansetron and palonosetron in thyroidectomy:a prospective,randomized,double-blind study[J]. Br J Anaesth,2012,108(3):417-422.
• [28] Cantarella PA,Chahl LA. Acute effects of morphine on Substance P concentrations in microdissected regions of guineapig brain[J]. Behav Pharmacol,1996,7(5):470-476.
• [29] Wan Q,Douglas SD,Wang X,et al. Morphine upregulates functional expression of neurokinin-1 receptor in neurons[J].J Neurosci Res,2006,84(7):1588-1596.
• [30] Passik SD,Lundberg J,Kirsh KL,et al. A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain[J]. J Pain Symptom Manage,2002,23(6):526-532.
• [31] Bhargava R,Chasen M,Elten M,et al. The effect of ginger(Zingiber officinale Roscoe)in patients with advanced cancer[J]. Support Care Cancer,2020,28(7):3279-3286.
• [32]中国临床肿瘤学会抗肿瘤药物安全管理专家委员会中国抗癌协会癌症康复与姑息治疗专业委员会.肿瘤治疗相关呕吐防治指南（2014版）[J].临床肿瘤学杂志，2014,19(3):263-273.