不同治疗方法对ACST大鼠死亡率的影响Effect of Different Therapeutic Methods on the Mortality Rate In ACST Rats Model
许锋,吴威中,胡立明,徐东琴
摘要(Abstract)：
本文对比观察了单纯胆管减压内引流(减压)、减压+氨苄青霉素、减压+“活血清解灵”对急性重症胆管炎(ACST)大鼠死亡率的影响.为探讨不同治疗方法的作用机制,我们来用生物学测定方法对大鼠腹腔巨噬细胞分泌的TNFa、IL-1、IL-6水平进行了测定,并以~(35)S标记的大肠杆菌为示踪物观察不同疗法对肠道细菌移位的影响.结果显示,ACST大鼠死亡率高达76%,减压组和氨苄组的死亡率相近(37.3%,36.8%),中药组的死亡率最低(25%).不同治疗方法对死亡率的影响与其对肠道细菌移位和巨噬细胞活化的抑制作用呈平行关系.
关键词(KeyWords)： 急性重症胆管炎;死亡率;细胞因子;细菌移位;治疗方法
基金项目(Foundation): 国家中医药管理局资助项目
作者(Author): 许锋,吴威中,胡立明,徐东琴
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