免疫检查点抑制剂相关性肺炎发病及治疗的中医思考Pathogenesis Analysis and Treatment Exploration in Traditional Chinese Medicine of Immune Checkpoint Inhibitor-related Pneumonitis
陈晨,贾立群,娄彦妮,索菲娅,郑佳彬
摘要(Abstract):
免疫检查点抑制剂相关性肺炎是恶性肿瘤患者免疫治疗的常见不良反应,目前机制尚未明确,治疗效果不理想。本文结合免疫治疗药物的中药化属性、免疫治疗相关肺炎易感人群的特征及其临床表现等,探讨免疫治疗相关肺炎的中医病机及治法。免疫治疗药物的中药属性为性阳热、升浮,味辛,归肺、脾、胃、肝经,易伤阴而生内热。免疫治疗相关肺炎的病机以肺之气阴两虚,或肺肾两虚,兼有肺中痰瘀阻滞络脉,络脉不通为主。治疗原则包括扶正与通络;扶正以益气养阴及补肺益肾为主;通络以化瘀通络、祛痰通络为主。本文探讨免疫治疗相关性肺炎的发病及治疗的中医认识,以期为临床应用提供参考。
关键词(KeyWords): 肺炎;免疫检查点抑制剂;中医;理论研究
基金项目(Foundation): 国家自然科学基金青年科学基金项目(81904003);; 北京市自然科学基金项目(7202184)
作者(Author): 陈晨,贾立群,娄彦妮,索菲娅,郑佳彬
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