蔡辉,赵智明,赵凌杰,董晓蕾

• 1:南京军区南京总医院

摘要(Abstract)：

目的探索淫羊藿总黄酮对高脂血症大鼠血清脂联素水平的影响及其改善内皮细胞作用的可能机制。方法将SD大鼠随机分为高脂饮食组(26只)和对照组(9只)。高脂饮食组高脂饮食喂养12周后,随机分为模型组(8只)和低剂量淫羊藿总黄酮组(9只)、高剂量淫羊藿总黄酮组(9只),灌胃相应药物4周后检测各组大鼠血脂水平并观察主动脉病理变化,采用ELISA法检测脂联素水平。结果与模型组比较,高、低剂量淫羊藿总黄酮组甘油三酯、总胆固醇水平降低(P<0.05或0.01),可明显减轻高脂饮食所致主动脉内皮损伤、内膜断裂,改善平滑肌增生,血清脂联素水平显著升高(P<0.01),并且高剂量组脂联素水平比低剂量组升高明显(P<0.05)。结论淫羊藿总黄酮能够调节血脂,提高血清脂联素水平。这与淫羊藿总黄酮改善内皮功能、抗动脉粥样硬化有关。

关键词(KeyWords)： 淫羊藿总黄酮;高脂血症;脂联素;血管内皮

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 蔡辉,赵智明,赵凌杰,董晓蕾

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