赵芳芳,徐敏,罗玉敏,李宁,黄礼媛,王平平,高利

• 1:首都医科大学宣武医院

摘要(Abstract)：

<正>脑血管病是导致人类死亡的三大疾病之一,在全球范围内每年使上百万的人死亡。中国是脑血管病死亡率高发地区。血脑屏障是脑毛细血管阻止某些物质由血液进入脑组织的结构,是血-脑、血-脑脊液和脑脊液-脑三种屏障的总称。

关键词(KeyWords)： 脑出血;脑梗死;血脑屏障

Abstract:

Keywords:

基金项目(Foundation): 北京市科技计划科技工作基础专项基金资助项目(项目编号:ZXW_2011_16)

作者(Author): 赵芳芳,徐敏,罗玉敏,李宁,黄礼媛,王平平,高利

参考文献(References)：

• [1]李中秋,陆兵勋.高血压脑出血患者血肿周围血2脑屏障超微结构的观察[J].临床神经病学杂志,2005,26(18):298.
• [2]Manley GT,Fujimura M,Ma T,et al.Aquaporin-4deletion in mice reduces brain edema after acute water toxication and is-chemic stroke[J].Nat Med,2000,6:159-163.
• [3]周敬华,曹学兵,孙圣刚.脑出血大鼠血肿周围组织水孔蛋白24表达分析[J].中国神经免疫学和神经病学杂志,2006,4(13):231-232.
• [4]周敬华,曹学兵,孙圣刚.V1α受体拮抗剂对脑出血大鼠水孔蛋白-4表达的影响及血脑屏障通透性的研究[J].中风与神经疾病杂志,2006,23(3):26.
• [5]王建平,刘佳.大鼠脑出血后血肿周围组织水通道蛋白-4表达与血脑屏障通透性的相关性[J].国际脑血管病杂志,2006,14(3):202-203.
• [6]王升武,李小刚.大鼠脑出血后水通道蛋白4的表达与血脑屏障超微结构变化的相关性研究[J].国际神经病学神经外科学杂志,2009,36(1):10-11.
• [7]唐宇平,蔡定芳,刘军,等.大黄改善急性脑出血大鼠血脑屏障损伤的水通道蛋白-4机理研究[J].中国中西医结合杂志,2006,26(2):153-154.
• [8]滕伟禹,高岩,田力,等.大鼠实验性脑出血后水通道蛋白4mRNA表达与血脑屏障通透性的关系[J].中国动脉硬化杂志,2006,14(4):331.
• [9]滕伟禹,刘宏丽,田力,等.大鼠实验性脑出血后血脑屏障通透性与水通道蛋白4的关系及水蛭素的作用研究[J].中国老年学杂志,2006,26(6):814-815.
• [10]苏建,娄季宇,王金兰,等.大鼠实验性脑出血后脑水肿与MMP29表达的关系及依达拉奉干预效应的研究[J].中国实用神经疾病杂志,2009,12(3):32-33.
• [11]刘宗超,饶明俐,张淑琴.实验性脑出血后脑水肿的动态变化及其与MMP-9的关系[J].中风与神经疾病杂志,2007,24(4):417.
• [12]祝春华,张祥建,刘春燕,等.实验性脑出血血肿周围MMP-9的表达与脑水肿的关系[J].中国全科医学,2004,7(23):1740.
• [13]Feiler S,Plesnila N,Thal SC,et al.Contribution of matrix metalloproteinase-9to cerebral edema and functional out-come following experimental subarachnoid hemorrhage[J].Cerebrovasc Dis,2011,32(3):289-95.
• [14]Rosell A,Ortega-Aznar A,Alvarez-Sabin J,et al.Increased brain expression of matrix metalloproteinase-9after ischemic and hemorrhagic human stroke[J].Stroke,2006,37:1399-1406.
• [15]Tejima E,Zhao BQ,Tsuji K,et al.Astrocytic induction of ma-trix metalloproteinase-9and edema in brain hemorrhage[J].J Cereb Blood Flow Metab,2007,27:460-468.
• [16]田力,滕伟禹,张威.大鼠脑出血后脑含水量的变化及水蛭素的干预作用[J].中国医科大学学报,2006,35(3):245.
• [17]Lee KR,Kawai N,Kim S,et al.Mechanisms of edema forma-tion after intracerebral hemorrhage:effects of thrombin on cerebral blood flow,blood-brain barrier permeability,and cell survival in a rat model[J].J Neurosurg,1997Feb,86(2):272-278.
• [18]张微微,黄勇华,揣兰香,等.鼠脑出血后部分脑区血管内皮生长因子表达与水含量变化[J].世界医学杂志,2003,7(1):60-62.
• [19]孟云,陈吉相,孙圣刚.脑室注射165对实验性脑出血大鼠血脑屏障的影响[J].卒中与神经疾病,2006,13(2):80-81.
• [20]Han Z,Wax MB,Patil RV.Regulation of aquaporin-4water channels by phorbol ester-dependent protein phosphoryla-tion[J].J Biol Chem,1998,237:6001-6004.
• [21]高修明,崔桂云,刘薇薇,等.H-7在脑出血后脑损伤中作用机制的研究[J].脑与神经疾病杂志,2009,17(5):348.
• [22]李中秋,陆兵勋,吕田明.高血压脑出血患者血肿周围血-脑屏障葡萄糖转运蛋白1表达的研究[J].临床神经病学杂志,2006,19(6):407.
• [23]李中秋,高正伟.高血糖对大鼠脑出血血脑屏障通透性的影响[J].医学临床研究,2007,24(3):440.
• [24]Mayne M,Ni W,Yan HJ,et al.Antisense oligodeoxynucleo tide in hibition of TNF-αexpression is neuroprotective after intracerebral hemorrhage[J].Stroke,2001,32(1):240-248.
• [25]Zhang Z,Kolls JK,Oliver P,et al.Activation of TNF-αon-verting enzyme mediated ectodomains hedding by nitricox-ide[J].J Biol Chem,2000,275:15839-15844.
• [26]Yang Y,Rosenberg GA.Blood-brain barrier breakdown in a-cute and chronic cerebrovascular disease[J].Stroke,2011Nov,42(11):3323-3328.
• [27]Rosell A,Alvarez-Sabin J,Arenillas JF,et al.Martrix metal-loproteinase protein array reveals a strong relation between MMP-9and MMP-13with diffusion-weighted in age lesion increase in human stroke[J].Stroke,2005,36:1415-1420.
• [28]Eldrup M,Gronholdt ML,Sillesen H,et al.Elevated matrix metalloprote inase-9associated with stroke or cardiovascular death in patients with carotid stenosis[J].Circulation,2006,114:1847-1854.
• [29]段东晓,焦喜涛,高晓群,等.低氧预处理对大鼠脑缺血再灌注后梗死体积和血脑屏障通透性的影响[J].河南实用神经疾病杂志,2004,7(2):7.
• [30]周其全,高钰琪,王静,等.氧自由基在高原暴露下血脑屏障通透性改变中的作用及其与脑水肿的关系[C].第12届中国体视学与图像分析学术年会论文集,2008:139-140.
• [31]Jaffer H,Morris VB,Stewart D.Labhasetwar V.Advances in Stroke Therapy[J].Drug Deliv Transl Res,2011Dec,1(6):409-419.
• [32]L-Name reduces infarction,neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice[J].European Journal of Pharmacology,2002,457:137-146.
• [33]Wallace BK,Jelks KA,O'Donnell ME.Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38and JNK MAP kinases[J].Am J Physiol Cell Physiol,2011N ov:2.
• [34]Perttu Johannes Lindsberg,Daniel Strbian,Marja-Liisa Kar-jalainen-Lindsberg.Mast cells as early responders in the reg-ulation of acute blood–brain barrier changes after cerebral ischemia and hemorrhage[J].J Cereb Blood Flow Metab,2010Apr,30(4):689-702.
• [35]Galli SJ,Gordon JR,Wershil BK.Cytokine production by mast cells and basophils[J].Curr Opin Immunol,1991,3:865-873.
• [36]Strbian D,Karjalainen-Lindsberg ML,Tatlisumak T,et al.Cerebral mast cells regulate early ischemic brain swelling and neutrophil accumulation[J].J Cereb Blood Flow Metab,2006,26:605-612.
• [37]Strbian D,Karjalainen-Lindsberg ML,Kovanen PT,et al.Mast cell stabilization reduces hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke[J].Circulation,2007,116:411-418.
• [38]Strbian D,Tatlisumak T,Ramadan UA,et al.Mast cell block-ing reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage[J].J Cereb Blood Flow Metab,2007,27:795-802.
• [39]Strbian D,Karjalainen-Lindsberg ML,Tatlisumak T,et al.Cerebral mast cells regulate early ischemic brain swelling and neutrophil accumulation[J].J Cereb Blood Flow Metab,2006,26:605-612.