辛味化瘀通络治法对脑梗死大鼠脑组织VEGF表达的影响
齐宝芳,邱幸凡,李娜
摘要(Abstract)：
目的研究辛味化瘀通络对脑梗死大鼠脑组织VEGF的蛋白表达及mRNA表达的影响。方法线栓法复制脑梗死大鼠模型。随机分为正常组、模型组、非辛味低剂量组、非辛味高剂量组、辛味低剂量组、辛味高剂量组。运用免疫组化、逆转录PCR检测大鼠脑组织VEGF的蛋白表达和mRNA表达。结果各化瘀通络组脑组织VEGF蛋白表达和mRNA表达与正常组有非常显著差异;辛味高剂量组与非辛味高剂量组有显著差异。结论化瘀通络能增强脑梗死大鼠脑组织VEGF的蛋白表达和mRNA表达,并与剂量呈一定的正相关性,且辛味化瘀通络的作用更加明显。
关键词(KeyWords)： 辛味化瘀通络;脑梗死;血管新生;血管内皮生长因子
基金项目(Foundation):
作者(Author): 齐宝芳,邱幸凡,李娜
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