苏懿,罗艳霞,赖彩辉,胡惠娟,马明远

• 1:广东省佛山市中医院广州中医药大学第八临床医学院

摘要(Abstract)：

目的 观察“四证四法”对脓毒症患者心功能障碍的防治效果。方法 将80例脓毒症患者按随机数字表法分为两组，观察组在对照组基础上用“四证四法”治疗。比较两组脓毒症心功能障碍（SIMD）发生率、心肌损伤和炎症指标变化和关系。结果 治疗后观察组SIMD发生率为41.03%，明显低于对照组的68.57%(P <0.05)；观察组患者白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、降钙素原（PCT）、肌钙蛋白Ⅰ（c TnⅠ）和N端B型脑钠肽前体（NT-proBNP）均低于治疗前（P <0.05），且观察组治疗后指标低于对照组（P <0.05）；观察组血管活性药物使用时间短于对照组（P <0.05）；患者的IL-6水平与NT-proBNP、PCT、IL-10水平均呈正相关，与左室射血分数（LVEF）呈负相关（P <0.05）。NT-proBNP水平与LVEF呈负相关，和PCT则呈正相关（P <0.01）。结论“四证四法”可以减低脓毒症患者SIMD的发生率，其作用机制可能与改善心肌损伤和调节炎症因子释放有关。

关键词(KeyWords)： 脓毒症心功能障碍;四证四法;心肌损伤;炎症

Abstract:

Keywords:

基金项目(Foundation): 佛山市医学类科技攻关项目（1920001000307）;; 佛山市竞争性扶持人才项目;; 佛山市工程技术研究中心认定项目（2120001009347）

作者(Author): 苏懿,罗艳霞,赖彩辉,胡惠娟,马明远

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