急性肺损伤动物模型研究进展
李竹英,王雪慧,刘建秋
摘要(Abstract):
<正>急性肺损伤(ALI)是由心源性以外的各种肺内外致病因素导致的急性、进行性缺氧性呼吸衰竭。临床上以急性进行性加重的呼吸困难、呼吸窘迫、难治性低氧血症和非心源性肺水肿为早期表现。其病因及发病机制错综复杂,致病环节众多,已成为临床危重病学研究的热点和难点。近年来对ALI的实验研究及发
关键词(KeyWords): 急性肺损伤;动物模型
基金项目(Foundation): 黑龙江省教育厅资助项目(11541328)
作者(Author): 李竹英,王雪慧,刘建秋
参考文献(References):
- [1]Schermuly RT,Gunther A,Weiss MN,et al.Differential inpact of ul-trasonically nebulized versus tracheal-instilled surfactant on ventila-tion(VA/Q)mismatch in a model of acute lung injury[J].Am J RespirCrit Care Med,2000,161(l):152-159.
- [2]Pelosi PD,Onofrio D,Chiumello D,et al.Pulmonary and extrapul-monary acute respiratory distress syndrome are different[J].Eur RespirJ,2003,22(Supppl 42),48-56.
- [3]Ricard JD,Dreyfuss D,Saumon G.Ventilar-induced lung in jury[J].Eur Respir J,2003,22(42):52-59.
- [4]EricKC,TomW,Arthur,etal.Effectsofcyclicopeningandclosingat low-and high-volume ventilation on bronchoalveolar lavage eytokines[J].Crit Care Med,2004,32(1):168-174.
- [5]Scott K,Joseph BZ,Weike T,et al.New clinically relevant sheepmodelsevererespiratoryfailuresecondaryto combined smokeinhalation/cutaneous flame burn injury[J].Crit Care Med,2002,28(5):1469-1476.
- [6]Koike K,Yamamoto Y.Hori Y Croup phospholⅡA phostholipase A2mediates lung in intestinal ischemia-reperfusion[J].Ann Surg,2000,232(1):90-97.
- [7]Catherine M,Michael A,Jean-Louis F.Pancreatitis-associated acutelung injury:new insights[J].Chest,2003,124(6):2341-2351.
- [8]Narayanan V.Pulmonary protective effects of curcumin againstParaquat toxicity[J].Life Sci,2000,66(2):21-28.
- [9]Michael AM,Guy AZ,Charles E,et al.Future research directions in a-cute lung injury:summary of a National Heart,Lung,and Blood Insti-tute Working Group[J].Am J Respir Crti Care Med,2003,167(7):1027-1035.