皮内针治疗慢性阻塞性肺疾病急性加重期的疗效观察
汪海燕;覃小静;黄秋萍;
摘要(Abstract)：
目的 观察皮内针治疗慢性阻塞性肺疾病（痰热壅肺证）急性加重期的疗效并探讨其作用机制。方法82例患者分为对照组与皮内针组各41例。对照组患者给予西医常规治疗，皮内针组患者给予西医常规联合皮内针治疗，疗程为7 d。比较两组中医证候疗效，观察两组治疗前后临床症状评分、中医证候积分、改良版英国医学研究委员会呼吸问卷（m MRC）评分、血气分析氧分压（PaO_2）、二氧化碳分压（PaCO_2）、血清炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白（hs-CRP）、降钙素原（PCT）]水平，记录两组无创通气时间、EICU平均住院时间和气管插管率。结果 皮内针组中医证候总有效率92.68%，高于对照组的75.61%(P <0.05)。两组治疗后咳嗽、咯痰、喘息评分、中医证候积分及mMRC评分明显降低（均P <0.05），皮内针组均低于对照组（均P <0.05）。治疗后，两组PaCO_2均明显降低（均P <0.05），皮内针组PaCO_2低于对照组（P <0.05）；两组治疗后PaO_2均明显升高（P <0.05），皮内针组高于对照组（P <0.05）。两组治疗后TNF-α、IL-6、PCT、hs-CRP均明显降低（均P <0.05），皮内针组均低于对照组（均P <0.05）。皮内针组咳机械通气时间、EICU住院时间均短于对照组（均P <0.05），气管插管率2.44%低于对照组的19.51%(P <0.05)。结论 皮内针治疗慢性阻塞性肺疾病（痰热壅肺证）急性加重期可以改善呼吸功能，缓解症状，抑制炎症反应，降低气管插管率。
关键词(KeyWords)： 慢性阻塞性肺疾病;急性加重期;皮内针;痰热壅肺证
基金项目(Foundation):
作者(Authors): 汪海燕;覃小静;黄秋萍;
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