衡炎方对脓毒症患者炎症反应及凝血功能的影响
周刚,张朝晖,瞿星光,龚勋,张蓉,曾超,李灵风
摘要(Abstract)：
目的观察中药衡炎方对脓毒症患者的疗效。方法 48例确诊为脓毒症的患者随机分为治疗组与对照组,除应用各自常规治疗外,治疗组另予衡炎方治疗;比较两组不同时段临床疗效及血小板(PLT)、C反应蛋白(CRP)及D-二聚体的变化。结果治疗组采用中药的临床疗效在不同时段均优于对照组,两组治疗3d后PLT均有下降,对照组下降明显;D-二聚体均有上升;CRP均有上升,对照组上升显著。治疗7d后,对照组PLT下降持续,CRP及D-二聚体均有上升,对照组更为显著。结论衡炎方治疗脓毒症患者有效。
关键词(KeyWords)： 脓毒症;炎症反应;凝血功能;衡炎方
基金项目(Foundation):
作者(Author): 周刚,张朝晖,瞿星光,龚勋,张蓉,曾超,李灵风
参考文献(References)：
- [1]Bone R C,Ball R A,Cerra F B,et al.Definitions for sepsisand organ failure and guidelines for the use of innovativetherapies in sepsis[J].Chest,1992,101(6):1644-1655.
- [2]宋继昌,周先亭.全身炎症反应综合征与中医的整体观念[J].中国中西医结合急救杂志,2003,10(6):329.
- [3]邹欣,陆付耳,涂胜豪,等.3种温病治法制剂改善内毒素血症人鼠生存率的研究[J].中国中西医结合急救杂志,2002,9(5):253-255.
- [4]Levi M,Vander PT,Buiier HR.Bidirectional relation betweeninflammation and coagulation[J].Circulation,2004,109:2698-2704.
- [5]Opal SM.The nexus between systemic inflammation and dis-ordered coagulation in sepsis[J].J Endotoxin Red,2004,10:125-129.
- [6]王鸿利.炎症-凝血网络与血栓形成的关系[J].外科理论与实践,2006,11(1):61-63.
- [7]Doshi S N,Mannur J D.Evolving role of tissue factor and itspathway inhibitor[J].Crit Care Med,2002,30(5):241-250.
- [8]汤大明,张红金,景炳文,等.血小板在危重病患者全身炎性反应监测中的意义[J].中国危重病急救医学,2003,15(1):35-37.
- [9]Nomura S,Kagawa H,Ozak Y,et al.Relationship betweenplatelet activation and cytokines in systemic inflammatory re-sponse syndrome patients with hematological malignancies[J].Thromb Res,1999,95(5):205-213.
- [10]潘曙明,王华,崔红,等.危重病人血小板计数改变与预后的关系[J].中国急救医学,2003,23(10):732-73.
- [11]Rey C,Losareas M,Concha A,et al.Procalcitonin and c-re-active protein as markers of systemic inflammatory responsesyndrome severity in critically ill children[J].Intensive CareMed,2007,33(3):477-484.
- [12]Querol-Ribelles J M,Tenias J M,Grau E,et al.Plasma d-dimer level correlate with outcomes in patients with communi-ty-acquired pneumonia[J].Chest,2004,126(4):1087-1092.