陈腾飞,肖斌,许钦,王施玮,陈波

• 1:福建中医药大学附属第二人民医院

摘要(Abstract)：

目的观察四逆汤对脓毒症(心肾阳衰证)患者C5a和C3a的影响。方法患者60例随机分为对照组与四逆汤组,每组30例。对照组参照指南给予常规治疗,四逆汤组在对照组的基础上加用四逆汤治疗,每日1剂,早晚温服或鼻饲,连续7 d或直至心肾阳衰证消失。分别于纳入研究的第1天、第3天及第7天以ELISA检测血清中C3a和C5a水平,比较急性生理与慢性健康评分量表Ⅱ(APACHEⅡ)评分、序贯器官衰竭评分表(SOFA)评分和28 d死亡率在组间的差异性。结果四逆汤组患者经治疗后,第3天及第7天检测的C5a水平均较第1天下降明显(P <0.05),且相较同期对照组水平更低(P <0.05)。而两组28 d死亡率以及C3a、APACHEⅡ评分和SOFA评分在治疗后第3天及第7天的比较均未发现明显差异(P> 0.05)。结论四逆汤能降低心肾阳衰脓毒症患者血清中C5a水平,这可能是其治疗脓毒症的部分机制。

关键词(KeyWords)： 脓毒症;四逆汤;C5a;C3a

Abstract:

Keywords:

基金项目(Foundation): 福建中医药大学校管课题资助项目（XB2018025)

作者(Author): 陈腾飞,肖斌,许钦,王施玮,陈波

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