初治继发性肺结核中医证型客观化研究Objective Study on TCM Syndrome Types of Untreated Secondary Pulmonary Tuberculosis
蒋菁蓉;高崇勇;张天洪;陈婧;涂翔;钟森;
摘要(Abstract):
目的探索初治继发性肺结核的中医证型分布规律与客观指标的联系。方法以150例初治继发性肺结核患者为研究对象,采集中医四诊信息及客观化指标,了解各证型的临床分布情况,并探讨各中医证型与实验室指标的关系。结果肺阴亏虚占60.67%,气阴两虚占20.67%,阴虚火旺占14.00%,肺脾两虚占2.00%,肺肾阴虚占2.00%,阴阳两虚占0.67%。肺阴亏虚证病程短于气阴两虚证(P<0.05)。各中医证型间的性别、年龄段、痰涂片、CD3+T、CD4+T、CD4+T/CD8+T、IL-2、IL-4、IL-6、IL-10、TNF-α比较差异无统计学意义(P>0.05)。肺阴亏虚证较阴虚火旺证、气阴两虚证CD8+T升高(P<0.05),阴虚火旺证较肺阴亏虚证、气阴两虚证IFN-γ升高(P<0.05)。结论初治继发性肺结核以肺阴亏虚证最多,依次为气阴两虚证、阴虚火旺证;病程长短、CD8+T细胞、IFN-γ与证型分布有相关性,为中医证型客观化研究提供了一定依据。
关键词(KeyWords): 肺结核;中医证型;客观化
基金项目(Foundation): 国家重大科技专项“十一五”课题(2008ZX10005-010)
作者(Authors): 蒋菁蓉;高崇勇;张天洪;陈婧;涂翔;钟森;
参考文献(References):
- [1]卫生部疾病预防控制局,卫生部医政司,中国疾病预防控制中心.中国结核病防治规划实施工作指南(2008版)[M].北京:中国协和医科大学出版社,2009:27-28.
- [2]中华中医药学会.中医内科常见病诊疗指南中医病证部分[M].北京:中国中医药出版社,2008:14-15.
- [3]周仲英.中医内科学[M].北京:中国中医药出版社,2007:107.
- [4]WHO.Provisional Guidelines on Standard International Age Classifications[EB/OL].http://unstats.un.org/unsd/publication/Series M/Series M_74.
- [5]张艳萍.秋季老年肺痨患者的辨证施护[J].湖北中医杂志,2002,24(7):55-56.
- [6]雷芳玉,刘定安,王博.肺结核辨病论治与辨证施治[J].陕西中医,2006,27(4):454-455.
- [7]王胜圣,田洋,刘嵋松,等.基于中医文献检索的肺结核病中医证候规律分析[J].中华中医药杂志,2011,26(11):2491-2493.
- [8]郑光琴.辨证治疗肺结核68例[J].四川中医,2000,18(7):20.
- [9]谢惠安,阳国太,林善梓,等.现代结核病学[M].北京:人民卫生出版社,2000:105-146.
- [10]Grotzke JE,Lewinsohn DM.Role of CD8+T lym phocytes in control of mycobacterium tuberculosis infection[J].Microbes Infect,2005,7(4):776-788.
- [11]Betts MR,Brenchley JM,Price DA,et al.Sensitive and viable identification of antigen-specific CD8+T cells by a flow cytometric assay for degranulation[J].J Immunol Methods,2003,281(1/2):65-78.
- [12]Vesosky B,Flaherty DK,Turner J.Th1 cytokines facilitate CD8-T-cell-mediated early resistance to infection with Mycobacterium tuberculosis in old mice[J].Infect Immune,2006,74(6):3314-3324.
- [13]Janssens J,Roux-Lombard P,Perneger T,et al.Contribution of a IFN-gamma assay in contact tracing for tuberculosis in a low-incidence,high immigration area[J].Swiss Med Wkly,2008,138(39):585-593.
- [14]Tsiouris SJ,Austin J,Toro P,et al.Results of a tuberculosisspecific IFN-gamma assay in children at high risk for tuberculosis infection[J].Int J Tubercu Lung Dis,2006,10(8):939-941.
- [15]Michael Lohoff,Hans-Willi Mittru cker,Stefen Prechtl,et al.Dysregulated T helper cell differentiation in the absence of interferon regulatory factor4[J].Proc Natl Acad Sci USA,2002,99(18):11808-11821.
- [16]Aly S,Laskay T,Mages J,et al.Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology:the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis[J].J Pathol,2007,212(3):295-305.