巨大维,魏品康,孙大志,修丽娟,陆烨,刘煊

• 1:第二军医大学附属长征医院

摘要(Abstract)：

目的观察消痰散结方对小鼠胃移植瘤和瘤旁胃组织中炎性因子白细胞介素6(IL-6)和白细胞介素8(IL-8)表达的调节作用,探讨消痰散结方抑瘤、防复发的部分作用机制。方法 40只昆明小鼠随机分为正常组、模型组、喃氟啶组、消痰散结方组;除正常组外,其余各组通过移植S180瘤块,建立小鼠胃移植瘤模型;实验3周后,剥取肿瘤,称取瘤质量,计算抑瘤率;运用RT-PCR及ELISA方法分别检测瘤及瘤旁胃组织中IL-6mRNA及IL-8蛋白表达。结果正常胃组织-瘤旁胃组织-瘤组织中IL-6、IL-8表达呈递增趋势;消痰散结方较喃氟啶可明显抑制肿瘤生长、下调肿瘤及瘤旁胃组织中IL-6、IL-8的表达。结论消痰散结方可明显下调胃肿瘤及瘤旁胃组织中IL-6、IL-8表达,是其抑瘤、防复发的可能机制之一。

关键词(KeyWords)： 消痰散结方;胃肿瘤;肿瘤移植;白细胞介素6;白细胞介素8

Abstract:

Keywords:

基金项目(Foundation): 国家自然基金重大研究计划面上项目(No.90709044);; 上海长征医院“三重三优”学科建设重大项目(2006-2010年)

作者(Author): 巨大维,魏品康,孙大志,修丽娟,陆烨,刘煊

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