郑燕;宣守松;张瑞;黄雪元;薛经纬;

• 1:上海市嘉定区中医医院

摘要(Abstract)：

目的 探讨宽胸理肺汤合三子养亲汤对COPD急性加重期（AECOPD）患者气道重塑及血清降钙素原（PCT）、超敏C反应蛋白（hs-CRP）的影响。方法 选取120例患者随机分为对照组与观察组各60例。对照组行常规吸氧、祛痰、平喘、抗感染对症支持治疗，观察组在对照组基础上联合宽胸理肺汤合三子养亲汤治疗。比较治疗前后两组患者中医证候积分、肺功能指标、炎症因子指标以及气道重塑指标。比较两组患者中医证候疗效。结果 观察组、对照组总有效率分别为96.67%、86.67%，观察组显著高于对照组（P <0.05）。治疗后观察组主症双肺啰音、喘息气短与中医证候积分低于对照组（P <0.05）;1秒用力呼气量（FEV1）、呼吸峰流速（PEF）、气道峰压（Ppeak）水平高于对照组（P <0.05）；白细胞介素-17(IL-17)、PCT、hs-CRP、碱性成纤维细胞生长因子（b-FGF）、基质金属蛋白酶-9(MMP-9)、内皮生长因子（VEGF）水平低于对照组（P <0.05）。结论 宽胸理肺汤合三子养亲汤对COPD急性加重期患者疗效确切，可降低血清PCT、CRP等炎症指标水平，改善患者肺功能与临床症状，有效抑制气道重塑。

关键词(KeyWords)： 慢性阻塞性肺疾病;急性加重期;降钙素原;气道重塑;宽胸理肺汤;三子养亲汤

Abstract:

Keywords:

基金项目(Foundation): 上海市嘉定区健康委员会中医药科研课题计划项目（2019-KY-ZYY-02）

作者(Authors): 郑燕;宣守松;张瑞;黄雪元;薛经纬;

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