颈痛汤配合针刺治疗对椎动脉型颈椎病患者血清IL-1β、NO、TGF-β_1的影响Th erapeutic Effects of Jingtong Decoction and Acupuncture on IL-1β,NO and TGF-β_1 in Vertebray Artery-type Cervical Spondylopathy
罗柳阳,郭福,郑献敏,黄丽华,梁建华
摘要(Abstract)：
目的观察颈痛汤配合针刺治疗对椎动脉型颈椎病(CSA)患者的临床疗效和血清白介素(IL)-1β、一氧化氮(NO)、转化生长因子(TGF)-β1的影响。方法 136例CSA患者随机分为治疗组和对照组各68例,治疗组采用颈痛汤配合针刺治疗,对照组采用口服盐酸氟桂利嗪胶囊和颈椎牵引治疗,68例健康对照组空白治疗。治疗后观察临床疗效和血清IL-1β、NO、TGF-β1的变化。结果治疗组与对照组的总有效率分别为91.18%和79.41%,差异有统计学意义(P<0.05)。治疗组血清IL-1β、NO、TGF-β1浓度治疗前后组内比较,差异有统计学意义(P<0.05);治疗后,治疗组与对照组比较,差异有统计学意义(P<0.05),与健康组比较差异无统计学意义(P>0.05)。结论颈痛汤配合针刺治疗临床疗效显著,对CSA患者血清IL-1β、NO、TGF-β1的影响明显。
关键词(KeyWords)： 颈痛汤;针刺;椎动脉型颈椎病;IL-1β;NO;TGF-β1
基金项目(Foundation): 广东省深圳市宝安区2012年科技计划(医疗卫生类)社会公益项目(2012183)
作者(Author): 罗柳阳,郭福,郑献敏,黄丽华,梁建华
参考文献(References)：
- [1]Solovieva S,Kouhia S,Leino-Arjas P,et al.Intervertebral disc degeneration in relation to the COL9A3 and the IL-1 as gene polymorphisms[J].Eur Spine,2006,15(5):613.
- [2]Kang JD,Stefanovic-Raccic M,McIntyre LA,et al.Toward a biochemical understanding of human intervertebral disc degeneration and herniation.contributions of nitric oxide,interleukins,prostaglandin E2,and matrix metall-proteinases[J].Spine,1997,22:1065-1073.
- [3]Liu GZ,Ishihara H,Osada R,et al.Nitric oxide mediate the changs of proteoglycan sythesis in the human lumbar intervertebral disc inresponse to hydrostatic pressure[J].Spine,2001,26(2):134-141.
- [4]Kang JD,Stefanovic M,Mclntyre LA,et al.Toward abiochemical understanding of human intervertebral disc de generation and herniation[J].Spine,1997,22(10):1065-1073.
- [5]Kohyama K,Saura R,Doita M.Intervertebral disc cell apoptosis by nitric oxide:biological understanding of intervertebral disc degeneration[J].Kobe J Med Sic,2000,46(6):283-295.
- [6]李进,杨述华,邵增务.细胞因子与椎间盘退行性变的关系[J].中国临床康复,2003,7(14):2079-2080.
- [7]裘淑荣,胡跃波,郝文杰,等.基因治疗兔颈椎间盘软骨终板钙化的实验研究[J].现代中西医结合杂志,2008,17(18):2775-2777.