补肾活血与益气活血方药对脑缺血老龄大鼠白介素-6和转化生长因子的影响The Influence of Drugs for Tonifying Kidney and Promoting Blood Circulation,for Increasing Qi and Promoting Blood Circulation,on the Levels of IL-6 and TGF in Aged Rats
周清安,李建生,王至婉,李小黎,侯秀娟
摘要(Abstract)：
目的探讨缺血性脑损伤病理及补肾活血与益气活血方药的防治机制,为其临床应用提供依据。方法观察补肾益元、活血通络之益元活血丹及益气活血通络之益气活血方对脑缺血老龄大鼠白介素-6(IL-6)和转化生长因子(TGF)水平的影响。结果与老龄假手术组比较,老龄模型组血清及脑组织IL-6水平明显升高,TGF水平显著降低;与老龄模型组对比,各灌药组脑组织IL-6水平降低,益气活血组与益元活血组血清IL-6水平降低、脑组织TGF水平升高。结论老龄大鼠急性脑缺血损伤可能与以下机制有关:(1)IL-6水平升高,加重脑组织缺血损伤;(2)TGF水平降低,减弱对脑组织保护作用。补肾活血和益气活血方药对急性脑缺血防护作用显著,其机制可能在于:抑制IL-6介导的脑组织损害作用;提高TGF水平,保护脑组织。两方药作用机制有所侧重,即益气活血方药降低脑组织IL-6,提高血清TGF水平;而益元活血方药降低血清IL-6、提高脑组织TGF水平较明显。
关键词(KeyWords)： 大鼠;脑缺血;老年;细胞因子;益元活血丹;益气活血方
基金项目(Foundation):
作者(Author): 周清安,李建生,王至婉,李小黎,侯秀娟
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