去甲斑蝥素诱导肿瘤细胞凋亡机制及临床应用前景的研究Study of Mechanism and Application View in Norcantharidin on Tumor Cell Apoptosis
常城,何仁胜,刘少平
摘要(Abstract):
去甲斑蝥素在肿瘤尤其是晚期肿瘤的治疗中有着非常好的应用前景。其机制可能与干扰肿瘤细胞生长周期,抑制DNA的合成代谢,影响细胞的有丝分裂、诱导细胞凋亡、抑制肿瘤细胞侵袭转移有关。其制剂已经越来越多地应用于临床实践中,并日益受到重视。本文综述近年来国内外NCTD抗肿瘤的作用机制及临床应用情况。
关键词(KeyWords): 去甲斑蝥素;抑制肿瘤机制;临床应用前景
基金项目(Foundation): 湖北省自然科学基金资助(2010CDB07401)
作者(Author): 常城,何仁胜,刘少平
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