自拟定眩汤治疗前庭神经炎(痰浊中阻证)的疗效观察Clinical Observation of Self-designed Dingxuan Decoction in Treating Vestibular Neuritis(Pattern of Phlegm-turbidity Obstructing Middle-jiao)
王智强,崔春丽,缪冬梅
摘要(Abstract):
目的 观察定眩汤治疗前庭神经炎(痰浊中阻证)的疗效。方法 患者91例随机分为对照组和治疗组。对照组采用常规激素加甲磺酸倍他司汀,治疗组在对照组的基础上加用自拟定眩汤,治疗7、14 d后进眩晕障碍量表(DHI)评分、冷热试验CP值、vHIT的增益、白细胞介素-6(IL-6)、中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、中医症状积分的变化。结果 治疗后治疗组的DHI评分、冷热试验CP值、IL-6、中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、中医症状单项积分、中医症状积分低于对照组(P<0.05);治疗组v HIT的增益高于对照组(P<0.05);治疗组的临床总有效率为91.30%,优于对照组的75.56%(P<0.05)。结论 定眩汤联合激素+倍他司汀对前庭神经炎(痰浊中阻证)治疗效果优于单纯使用激素加倍他司汀。
关键词(KeyWords): 前庭神经炎;眩晕;定眩汤;痰浊中阻证
基金项目(Foundation): 国家中医药管理局课题(2019XZZX-NB007)
作者(Author): 王智强,崔春丽,缪冬梅
参考文献(References):
- [1]Strupp M,Magnusson M.Acute unilateral vestibulopathy[J].Neurol Clin,2015(33):669.
- [2]Adamec I,Krbot Skoric M,Handzic J,et al.Incidence,seasonality and comorbidity in vestibular neuritis[J].Neurol Sci,2015(36):91.
- [3]Himmelein S,Lindemann A,Sinicina I,et al.Differentialinvolvement during latent herpes simplex virus linfection of the superior and inferior divisions of the vestibular ganglia:implications for vestibular neuritis[J].J Virol,2017(91):900331.
- [4]袁源.前庭神经炎诊治新进展[C].中华中医药学会耳鼻喉科分会、世界中联耳鼻喉口腔科专业委员会.中华中医药学会耳鼻喉科分会第二十三次学术年会、世界中联耳鼻喉口腔科专业委员会第九次学术年会论文集,2017:121-122.
- [5]孔维佳.耳鼻咽喉头颈外科学[M].北京:人民卫生出版社,2010:445-449.
- [6]国家中医药管理局.中医病证诊断疗效标准:ZY/T001.1-94[S].南京:南京大学出版社,1994:271-275.
- [7]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:235-239.
- [8]Taylor RL,Mc Garvie LA,Reid N,et al.Vestiblar neuritisaffects both superior and inferior vestibular nerves[J].Neurology,2016(87):1704.
- [9]Xu Xd,Zhang Q,Hu J,et al.The hidden loss of otolithic function in children with profound sensorineural hearing loss[J].Int J pediatr Otorhinolaryngol,2015,79(6):852-857.
- [10]胡娟,张青.眼肌前庭诱发肌源性电位的研究现状及展望[J].临床耳鼻咽喉头颈外科杂志,2013,27(7):388-392.
- [11]吕亚峰,张道宫,樊兆民,等.前庭神经炎患者前庭功能损伤的频率和部位特征分析[J].临床耳鼻咽喉头颈外科杂志,2016,30(8):602-605.
- [12]Kassner SS,Schottler S,Bonaterra GA,et al.proinflammatory activation of peripheral blood mononuclearcells in patients with vestibularneuritis[J].Audiol Neurootol,2011,16(4):242-247.
- [13]Ozbay I,Kahraman C,Balikci H,et al.Neutrophil-to-lymphocyte ratio in patients with peripheral vertigo:a prospective controlled clinical study[J].Am J Otolaryngol,2014,35(6):699-702.
- [14]Chung JH,Lim J,Jeong JH,et al.The significance of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in vestibular neuritis[J].Laryngoscope,2015,125(7):e257-261.
- [15]周倩,吴皓.半夏总生物碱抗炎作用研究[J].中药药理与临床,2006,22(4):87-89.
- [16]薛柳华,唐一鹏,洪庆涛,等.天麻素对谷氨酸致培养皮层神经细胞损伤的保护作用[J].北京中医药大学学报,1999,41(1):40-41.
- [17]Li G,Xu Y,Sheng X,et al.Naringin protects against high glucose-induced human endothelial cell injury via antioxidation and CX3CL1 ownregulation[J].Cell physiol Biochem,2017,42(6):2540-2551.
- [18]奚清,金银花提取物活性成分对甲型流感病毒肺炎小鼠免疫细胞因子表达影响的实验研究[D].沈阳:辽宁中医药大学,2008.
- [19]王越欣,王梅,李宁,等.连翘抗炎活性及作用机理研究进展[J].中华中医药学刊,2021,30(4):6.