早发冠心病血瘀证的分子生物学研究现状和探讨
陈伶利,李杰,袁肇凯,瞿岳云
摘要(Abstract):
<正>冠心病是威胁人类健康的重要疾病。流行病学结果显示,今后20多年中,冠心病发病和死亡率在世界范围内仍呈上升趋势,并且发病年龄越来越年轻。目前治疗冠心病耗资巨大,花费的资金已成为世界各国严重的医疗负担。现在共识是治疗冠心病应包括两层意义:一是冠心病易患因素(危险因素)的控制,二
关键词(KeyWords): 早发冠心病;血瘀证;分子生物学;研究现状
基金项目(Foundation): 国家自然科学基金项目(81001518,30973717);; 湖南省中医药科研计划项目(2010010)
作者(Author): 陈伶利,李杰,袁肇凯,瞿岳云
参考文献(References):
- [1]陈可冀.中西医结合内科学[M].北京:中国中医药出版社,2001:159.
- [2]陈君,郭志刚,胡威,等.早发冠心病患者危险因素和冠状动脉的病变特点[J].广东医学,2009,30(5):737-739.
- [3]竟雪莹,马根山,陈忠.纤维蛋白原β基因启动子-845G/A多态性与早发冠心病相关性[J].蚌埠医学院学报,2009,34(3):206-208.
- [4]王加红,陈忠,马根山,等.妊娠相关蛋白A基因多态性与早发冠心病相关性研究[J].临床心血管病杂志,2009,25(6):433-435.
- [5]马会利,郭志红,赵红,等.≤45岁早发冠心病患者危险因素分析[J].现代预防医学,2008,35(20):3917-3918.
- [6]许瑛杰,王绿娅.脂质代谢相关基因变异在早发冠心病中作用的研究进展[J].遗传,2008,30(6):671-676.
- [7]Cam SF,Sekuri C,Sagcan A,et al.Effect of monocyte chemoattractantprotein-1(MCP-1)gene polymorphism in Turkish patients with pre-mature coronary artery disease[J].The Scandinavian Journal of Clini-cal and Laboratory Investigation,2008,68(8):801-805.
- [8]Chen Zhong,Zhang Luzhan,Ma Genshan,et al.Monocyte chemoat-tractant protein-1-2518 G/A polymorphism,plasma levels,and pre-mature stable coronary artery disease[J].Molecular Biology Reports,2010,37(1):7-12.
- [9]Sekuri C,Cam FS,Sagcan A,et al.NO associ-Tion of interleukin-6gene polymorphism(-174 G/C)with premature coronary Artery dis-ease in a Turkish cohort[J].Coronary arterydisease,2008,18(5):333-337.
- [10]Nastos P,Nikolakis D,Lamnissou K.Lack of association between en-dothelial nitric oxide synthase gene polymorphisms and risk of prema-ture coronary artery disease in the Greek population[J].Acta Cardio-logica,2008,63(5):609-614.
- [11]袁肇凯,田松,黄献平,等.长沙地区冠心病中医证型的临床流行病学研究[J].中华中医药学刊,2008,26(8):1605-1608.
- [12]李杰,袁肇凯.冠心病血瘀证的病机研究[J].中西医结合心脑血管病杂志,2006,4(7):613-614.
- [13]张凤蛾,瞿岳云.关于建立证型基因表达谱数据库的设想[J].山西中医学院学报,2002,3(3):1-3.
- [14]王阶,杨保林,姜燕.冠心病血瘀证相关基因研究[J].世界科学技术:中医药现代化,2005,7(1):17-19.
- [15]马晓娟,殷惠军,陈可冀.血瘀证患者差异基因表达谱研究[J].中西医结合学报,2008,6(4):355-360.
- [16]袁肇凯,黄献平,毛以林,等.心血瘀阻证遗传倾向的调查分析[J].湖南中医学院学报,2003,23(3):54-56.
- [17]毛以宁.冠心病血瘀证分布特征探讨[J].湖南中医药导报,2004,10(5):5-6.
- [18]毛以宁,袁肇凯,黄献平,等.冠心病血瘀证与血管紧张素转换酶基基因多态性的相关性研究[J].中国中西医结合杂志,2004,24(9):776-780.
- [19]黄献平,袁肇凯,毛以林,等.冠心病血瘀证凝血因子Ⅶ基因多态性的检测分析[J].中西医结合心脑血管病杂志,2006,4(2):97-99.
- [20]李杰,袁肇凯,黄献平,等.湖南汉族人群ACEI/D基因多态性与冠心病血瘀证的遗传流行病学研究[J].中西医结合心脑血管病杂志,2007,5(9):787-789.
- [21]李杰,袁肇凯,黄献平,等.湖南汉族人群FⅦ基因M1/M2多态性与冠心病血瘀证的遗传流行病学研究[J].中国中医急症,2009,18(2):253-255.
- [22]袁肇凯,黄献平,谭光波,等.冠心病血瘀证ApoE基因多态性的检测分析[J].北京中医药大学学报,2008,31(12):830-834.
- [23]李定祥,杨军辉,邓弈辉.冠心病血瘀证各亚型与纤溶系统活性相关性探讨[J].中国中医药现代远程教育,2007,5(5),8-10.
- [24]胡志希,陈娟.早发冠心病血瘀证与痰浊证的研究现状与对策[J].中西医结合心脑血管病杂志,2007(8):659-661.
- [25]胡志希,袁肇凯,陈洁,等.早发冠心病血瘀证痰浊证面部光电血流容积特征及与一氧化氮、内皮素含量的相关研究[J].中国中医药信息杂志,2009,16(3):19-21.
- [26]胡志希,袁肇凯,陈娟,等.早发冠心病血瘀证面部光电血流容积特征与HbO2的相关研究[J].湖南中医药大学学报,2009,29(2):26-28.
- [27]Tyler AL,Asselbergs FW,Williams SM,et al.Shadows of complexi-ty:what biological networks reveal about epistasis and pleiotropy[J].Bioessays,2009,31(2):220-227.
- [28]Pearson TA,Manolio TA.How to interpret a genome-wide associationstudy[J].Jama,2008,299(11):1335-1344.
- [29]Wang K,Zhang H,Kugathasan S,et al.Diverse genome-wide associa-tion studies associate the IL12/IL23 pathway with crohn disease[J].Am JHum Genet,2009,84(3):399-405.
- [30]Perry JR,McCarthy MI,Hattersley AT,et al.Nterrogating Type 2 Dia-betes Genome-Wide Association Data Using a Biological Pathway-Based pproach[J].Diabetes,2009,58(6):1463-1467.
- [31]Elbers CC,Van Eijk KR,Franke L,et al.Using Genome-wide pathwayanalysistounraveltheetiologyofcomplexdiseases[J].GenetEpidemiol,2009,33(5):419-431.
- [32]Torkamani A,Topol EJ,Schork NJ.Pathway analysis of seven commondiseases assessed by genome-wide association[J].Genomics,2008,92(5):265-272.
- [33]Goh KI,Cusick ME,Valle D,et al.The human disease network[J].Proc Natl Acad Sci USA,2007,104(21):8685-8690.
- [34]Barabasi AL.Network medicine-from obesity to the“diseasome”[J].N Engl J Med,2007,357(4):404-407.
- [35]Huang W,Wang P,Liu Z,et al.Identifying disease associations viagenome-wide association studies[J].BMC Bioinformatics,2009,10(Supp1)1:S68.
- [36]Lynn KS,Hsu WL,Li LL,et al.A Neural Network Model for Con-structing Endophenotypes of Common Complex Diseases:-An Appli-cation to Male Young-onset Hypertension Microarray Data[J].Bioin-formatics,2009,25(8):981-988.