中药口服配合灌肠治疗溃疡性结肠炎的临床观察及对肠黏膜IL-6、IL-10的影响The Clinical Observation of Oral Traditional Chinese medicine combined with Enema on Ulcerative Colitis and the Efficacy on Intestinal Mucosal IL-6、IL-10
冯春霞,张强,陈晓蓉,穆桂萍,黄明河
摘要(Abstract)：
目的观察理肠汤口服结合溃疡灵灌肠治疗溃疡性结肠炎(UC)的临床疗效,并检测患者结肠黏膜组织中的IL-6、IL-10的表达情况。方法将UC患者60例随机分为治疗组30例与对照组30例,治疗组给予理肠汤口服及溃疡灵灌肠;对照组给予虎地胶囊口服,两组均治疗2个月。治疗结束后进行临床疗效比较,并利用免疫组化的方法,检测结肠黏膜组织中IL-6、IL-10在治疗前后的表达。结果两组治疗后均能改善腹泻、脓血便、腹痛等主要临床症状(P<0.05),治疗组优于对照组(P<0.05);治疗组总有效率高于对照组(P<0.05);两组均能降低IL-6的阳性表达率、提高IL-10的阳性表达量(P<0.05),治疗组优于对照组(P<0.05)。结论理肠汤口服结合溃疡灵灌肠治疗UC有较好的临床疗效,能够明显改善患者症状,减轻肠黏膜炎症,降低肠黏膜IL-6的表达、升高IL-10的表达。
关键词(KeyWords)： 溃疡性结肠炎;中医药治疗;理肠汤;溃疡灵;IL-6;IL-10
基金项目(Foundation): 广东省深圳市科技计划项目(201003172)
作者(Author): 冯春霞,张强,陈晓蓉,穆桂萍,黄明河
参考文献(References)：
- [1]中国中西医结合学会消化系统疾病专业委员会.溃疡性结肠炎中西医结合诊治方案[J].中国中西医结合消化杂志,2011,19(1):61.
- [2]Koppetal.inhibition of NF-KB By sodiam salicylate and aspirin[J].Science,1944,265:956-959.
- [3]Lshiguro Y.Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis[J].J Gastroenteror,1999,34(1):66.
- [4]Holtkamp W,Stollberg T,Reis HE.Serum interleukin-6 is related to disease activity but not disease specificity in inflammatory bowl disease[J].Clin Gast-roenterol,1995,20(2):123.
- [5]Holub MC,Mako E,Devay T,et al.Increased interleukin-6levels,interleukin-6 receptor and gpi30 expression in peripheral lymphocytes of patients with inflammatory bowl disease[J].Scand J Gastroenterol,1998,33suppl 228:47.
- [6]Daig R,Andus T,Aschenbrenner E,et al.Increased interleukin-8 expression in the colon mucosa of patients with imflammatory bowl disease[J].Gut,1996,38:26.
- [7]Melgar S,Yeung M,Bas A.et al.Over-expression of interleukin-10 in mucosal Tcells of patients with active ulcerative colitis[J].Clin Exp Immunol 2003,134:127-137.