Nogo蛋白及其受体与中枢神经再生
宋红普,魏江磊,石敏
摘要(Abstract)：
<正>成人中枢神经损伤后不能再生。除了与胶质疤痕的空间阻碍作用和促神经生长因子的缺乏以外,主要是由于中枢神经系统中存在着抑制神经细胞生长的抑制因子。其中,Nogo蛋白作为抑制中枢神经系统再生的最重要的物质[1],越来越受到人们的重视。
关键词(KeyWords)： Nogo蛋白;NgR;神经再生
基金项目(Foundation):
作者(Author): 宋红普,魏江磊,石敏
参考文献(References)：
- [1]范有名.NgR受体复合物介导中枢神经再生抑制机制研究[J].华南国防医学杂志,2010,24(1):72-74.
- [2]Walmsley A R,MIR A K.Targeting the Nogo-A Signalling Pathway toPromote Recovery Following Acute CNS Injury[J].Curr Pharm Des(S1381-6123),2002,137:361-369.
- [3]杨明,唐洪涛.中枢神经系统中Nogo与Nogo-R的研究进展[J].解剖学研究,2008,30(1):65-67.
- [4]Chen Y,Tang X,Cao X,et al.Human Nogo-C overexpression inducesHEK293 cell apoptosis via a mechanism that involves JNK-c-Jun path-way[J].Biochem Biophys Res Commun(S0006-291X),2006,348(3):923-928.
- [5]Zhang S,Zhang Q,Zhang J H,et al.NHR Acts as an Inhibitor to Axon-al Regeneration in Adults[J].Front Biosci(S1093-9946),2008,1(13):2030-2040.
- [6]Ng C E,Tang B L.Nogos and the Nogo-66 receptor family member,TROY,is a coreceptor with Nogo receptor in mediating the inhibitoryactivity of myelin inhibitors[J].Neuron,2005,45(3):345-351.
- [7]Yamashita T,Tohyama M.The p75 receptor acts as a displacementfactor thatreleases Rho from Rho-GDI[J].Nat Neurosci,2003,6(5):461-467.
- [8]Mi S,Lee X,Shao Z,et al.LINGO-1 is a component of the Nogo-66recept.or/p75 signaling complex[J].Nat Neurosci,2004,7(3):221-228.
- [9]Park J B,Yiu G,Kaneko S,et al.A TNF receptor family member,TROY,is a coreceptor with Nogo receptor in mediating the inhibitoryactivity of myelin inhibitors[J].Neuron,2005,45(3):345-51.
- [10]Shao Z,Browning J L,Lee X,et al.TAJ/TROY,an orphan TNF recep-tor family member,binds Nogo-66 receptor 1 and regulates axonal re-generation[J].Neuron,2005,45(3):353-359.
- [11]Niederost B,Oertle T,Fritsche J,et al.Nogo-A and Myelin-associatedGlycoprotein Mediate Neurite Growth Inhibition by Antagonistic Reg-ulation of RhoA and Racl[J].Neurosci(S0270-6474),2002,22(23):10368-10376.
- [12]Chen J,Cuerriero E,Lathrop K,et al.Rho/ROCK Signaling in Regu-lation of Corneal Epithelia Cell Cycle Progression[J].Invest Ophthal-mol Vis Sci(S0146-0404),2008,49(1):175-183.
- [13]熊南翔,赵洪洋,张方成,等.钙离子参与Nogo-A抑制轴突生长的作用[J].解剖学报,2005,36(6):582-585.
- [14]王席玲,邹忆怀,朱陵群.Nogo-A蛋白与中枢神经损伤再生关系的研究进展[J].中西医结合心脑血管病杂志,2007,5(11):1094-1096.
- [15]GrandPre T,Li S,Strittmatter S M.Nogo-66 receptor antagonist peptidepromotes axonal regeneration[J].Nature,2002,417(4):547-551.
- [16]Li S,Strittmatter S M.Delayed systemic Nogo-66 receptor antagonistpromotes recovery from spinal cord injury[J].Neuron,2004,44(4):439-451.
- [17]Kim J E,Liu B P,Park J H,et al.Nogo-66 receptor prevents raphes-pinal and rubrospinal axon regeneration and limits functional recoveryfrom spinal cord injury[J].Neuron,2004,44(4):439-451.
- [18]高晓玉,王得新,张拥波.Nogo-A在脑缺血再灌注白质损伤中的表达及其意义[J].中国老年学杂志,2009,29(18):2323-2325.
- [19]张利军,白宇,候郁青,等.三七三醇皂苷对局灶性脑缺血再灌注大鼠脑组织Nogo-A表达的影响[J].中医药导报,2008,14(5):11-14.
- [20]王中琳.缺血性脑卒中模型大鼠脑内Nogo-A的表达及中药干预作用[J].中医药信息,2009,26(4):71-73.
- [21]胡怀强,周永红,马学盛,等.复健片对大鼠脑梗死后不同时间点Nogo-A表达的影响[J].中国实验动物学报,2010,18(2):118-121.