中医药防治EGFR-TKI不良反应的研究进展
文俊,尹晓然,全建峰
摘要(Abstract):
肺癌是目前全球发病率之首的恶性肿瘤,表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI)的临床运用可以让相关基因优选人群肿瘤的发生发展得到有效的控制,临床症状得到缓解,在延长总生存期的同时改善生活质量。但在口服EGFR-TKI过程中,相关不良反应的发生会降低这类人群的生活质量,甚至导致死亡。在口服EGFR-TKI的同时配合使用中医药,可以有效降低不良反应的发生率,使不良反应的症状得到一定程度缓解,对于提升患者生活质量及延长生存期也有一定的优势。
关键词(KeyWords): 非小细胞肺癌;靶向治疗;EGFR-TKI;不良反应;中医药;综述
基金项目(Foundation): 国家自然科学基金面上项目(81072757/H2708)
作者(Author): 文俊,尹晓然,全建峰
参考文献(References):
- [1] Bray F,Ferlay J,Soerjomataram I,et al. Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA:A Cancer Journal for Clinicians,2018,68(6):1-31.
- [2] Scott G,Leora H,David J,et al. Five-Year Follow-Up of nivolumab in previously treated advanced Non-Small-Cell lung cancer:results from the CA209-003 Study[J]. Journal of Clinical Oncology,2018,30(17):1675-1684.
- [3]胡宏祥,王学清,张华,等.分子靶向抗肿瘤药物的作用机制及临床研究进展[J].药学学报,2015,50(10):1232-1239.
- [4]李鑫,汪品嘉,姚文秀. EGFR抑制剂相关皮肤不良反应研究进展[J].肿瘤预防与治疗,2017,30(6):459-464.
- [5] Peuvrel L,Bachmeyer C,Reguiai Z,et al. Semiology of skin toxicity associated with epidermal growth factor receptor(EGFR)inhibitors[J]. Support Care Cancer,2012,20(5):909-921.
- [6]邓博.中医药防治分子靶向治疗药物相关不良反应的研究进展[J].中华中医药学刊,2018,36(7):1580-1583.
- [7]童莹慧,方罗,丁海樱,等.表皮生长因子受体抑制剂相关性皮肤毒性的研究进展[J].中国现代应用药学,2018,35(2):293-301.
- [8]张誉华.养肺消疹方治疗肺癌靶向药物相关性皮疹的临床观察[J].中华中医药杂志,2016,31(1):100-103.
- [9]宋爱英,陈端洪,邹香妮.加味枇杷清肺饮治疗EGFR-TKI致皮损的临床疗效观察[C].世界中医药学会联合会肿瘤经方治疗研究专业委员会成立大会暨学术年会,2015.
- [10]陈碧茵.八宝丹胶囊治疗表皮生长因子受体拮抗剂相关性皮疹临床观察[J].临床合理用药杂志,2017,10(31):58-59.
- [11]王红岩,邹超,崔慧娟,等.止痒平肤液治疗表皮生长因子受体拮抗剂相关皮肤不良反应的疗效观察[J].中国中西医结合杂志,2015,35(7):820-822.
- [12]李向莲,唐雪莉,李幼平,等. EGFR-TKI与化疗比较一线治疗晚期非小细胞肺癌有效性和安全性的系统评价[J].中国循证医学杂志,2016,16(2):191-199.
- [13] Hirsh V. Managing treatment-related adverse events associated with egfr tyrosine kinase inhibitors in advanced nonsmall-cell lung cancer[J]. Curr Oncol,2011,18(3):126-138.
- [14] Rosell R,Carcereny E,Gervais R,et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-smallcell lung cancer(EURTAC):a multicentre,open-label,randomised phase 3 trial[J]. Lancet Oncol,2012,13(3):239-246.
- [15] Inoue A,Kobayashi K,Maemondo M,et al. Updated overall survival results from a randomized phaseⅢtrial comparing gefitinib with carboplatin-paclitaxel for chemo-naive nonsmall cell lung cancer with sensitive EGFR gene mutations(NEJ002)[J]. Ann Oncol,2013,24(1):54-59.
- [16] Maemondo M,Inoue A,Kobayashi K,et al. Gefitinib or chemo therapy for non-small-cell lung cancer with mutated EGFR[J]. N Engl J Med,2010,362(25):2380-2388.
- [17] Janjigian YY. Lapatinib in Gastric Cancer:What Is the LOGiCal Next Step[J]. J Clin Oncol,2016,34(5):401-403.
- [18] Ramlau R,Thomas M,Novello S,et al. Phase I study of lapatinib and pemetrexed in the second-line treatment of advanced or metastatic Non-small-cell lung cancer with assessment of circulating cell free thymidylate synthase RNA as a potential biomarker[J]. Clin Lung Cancer,2015,16(5):348-357.
- [19] Bowen JM. Mechanisms of TKI-induced diarrhea in cancer patients[J]. Curr Opin Support Palliat Care,2013,7(2):162-167.
- [20]胡玲娜.分子靶向药物EGFR酪氨酸激酶抑制剂诱导的肠上皮损伤及其机制[D].南京:南京大学,2012.
- [21]黄晓明,孙建立,宋晨菲.养阴解毒法在中医药结合EGFR-TKI治疗晚期非小细胞肺癌中的思路探讨[J].时珍国医国药,2015,26(7):1706-1708.
- [22]胡洁,林丽珠,骆肖群,等. EGFR-TKI不良反应管理专家共识[J].中国肺癌杂志,2019,22(2):57-81.
- [23]刘浩,侯炜,王辉,等.参一胶囊联合吉非替尼治疗晚期非小细胞肺癌50例临床研究[J].中医杂志,2012,53(11):933-935,966.
- [24]张琇文,邵怿,张欣欣,等.参苓白术颗粒联合吉非替尼/厄罗替尼治疗脾气虚型晚期非小细胞肺癌临床研究[J].新中医,2014,46(1):127-129.
- [25]邓博.中医药防治分子靶向治疗药物相关不良反应的研究进展[J].中华中医药学刊,2018,36(7):1580-1583.
- [26]张小瑞,赵远红.非小细胞肺癌靶向药物相关皮肤毒性反应的中医辨治[J].中医杂志,2015,56(12):1065-1066.
- [27]王红岩,邹超,崔慧娟,等.外用清热利湿中药治疗表皮生长因子受体拮抗剂相关皮疹120例临床研究[J].北京中医药大学学报:中医临床版,2013,20(4):14-17.
- [28]邹超.外用中药制剂治疗EGFR-TKIs相关皮肤干燥的临床研究[D].北京:北京中医药大学,2013.
- [29]徐央波. 4种外用药物治疗EGFR-TKIs皮肤干燥的自身对照临床研究[D].北京:北京中医药大学,2015.
- [30] Teng WC,Oh JW,New LS,et al. Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib[J]. Mol Pharmacol,2010,78(4):693-703.
- [31] Teo YL,Ho HK,Chan A. Risk of tyrosine kinase inhibitorsinduced hepatotoxicity in cancer patients:A meta-analysis[J]. Cancer Treatment Reviews,2013,39(2):199-206.
- [32] Suzumura T,Kimura T,Kudoh S,et al. Reduced CYP2D6function is associated with gefitinib-induced rash in patients with non-small cell lung cancer[J]. BMC Cancer,2012,12(1):568.
- [33]李保义,吕晓峰,安春棉,等.茵陈蒿汤加味治疗药物性肝损伤65例[J].中国实验方剂学杂志,2013,19(20):285-288.
- [34]黄智芬,黎汉忠,谭志强,等.茵陈蒿汤加味治疗肿瘤化疗药物所致肝损害30例[J].中西医结合肝病杂志,2011,21(1):48-50.
- [35]王爱华,张志.柴胡栀子汤治疗抗痨药物所致肝损害52例[J].光明中医,2012,27(10):2033-2034.
- [36]梁红梅,朱清静.芍药甘草汤联合综合疗法治疗慢性重度乙型肝炎临床研究[J].中西医结合肝病杂志,2018,28(3):142-144.
- [37] Maemondo M,Minegishi Y,Okinaga S,et al. First-line gefitinib therapy for elder advanced non-small cell lung cancer patients with epidermal factor receptor mutations:multicenter phaseⅡtrial[J]. Clin Oncol,2009,27(9):1394-1400.
- [38]罗长琴,王丽娜,李雨遥,等.吉非替尼致间质性肺炎并文献回顾[J].现代肿瘤医学,2012,20(9):1858-1862.
- [39]张心月,贾新华.特发性间质性肺炎“血运失常”病机本质探析[J].中医药信息,2017,34(5):3-5.
- [40]李宁.通络化痰祛瘀法治疗间质性肺疾病(痰瘀阻肺型)的临床研究[D].长春:长春中医药大学,2012.
- [41]沈越.中药治疗44例间质性肺炎的临床效果分析[J].中医临床研究,2012,4(6):79-80.
- [42]江雨晨,尤建良.尤建良教授治疗肺癌经验[J].湖南中医药大学学报,2015,35(4):39-40.