天花粉对脑缺血再灌注大鼠高同型半胱氨酸血症的影响Effect of Trichosanthin on High Plasma Homocystein in Rats with Cerebral Ischemia-reperfusion
陈威,王红,张思为
摘要(Abstract)：
目的研究天花粉对脑缺血再灌注大鼠高同型半胱氨酸血症(Hhcy)的影响,并通过对缺血周围区细胞周期蛋白A的检测,进一步探讨天花粉对缺血再灌注影响的分子机制。方法采用大鼠脑缺血再灌注模型,随机分为假手术组、模型组、天花粉组、补阳还五汤组。术后分12、24、48h 3个时间点行神经功能评分;检测血浆中Hcy含量;免疫组化观察缺血周围区细胞周期蛋白A表达强度。结果神经功能评分显示与模型组比较,天花粉组、补阳还五汤组神经功能有显著改善;血浆Hcy含量与模型组比较,各治疗组均显著减少;细胞周期蛋白A阳性细胞表达水平缺血再灌注12h,与模型组比较,天花粉组、补阳还五汤组阳性细胞数显著减少。缺血再灌注24h和缺血再灌注48h,治疗组与模型组比较,阳性细胞数均显著减少,天花粉组与补阳还五汤组比较也显著减少。结论天花粉能减轻缺血再灌注后大鼠Hhcy的程度,和补阳还五汤相比其改善脑缺血再灌注的机制可能和细胞周期蛋白相关。
关键词(KeyWords)： 脑缺血再灌注;同型半胱氨酸;细胞周期蛋白A;天花粉;补阳还五汤
基金项目(Foundation):
作者(Author): 陈威,王红,张思为
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